Jim Simons Biotechnology

Renaissance Technologies LLC

$63.4 Billion
Q4 2024

Stock List

Stock	Market Cap.	Holding Value (Reported)	# of Shares.	Last Trade
UTHR United Therapeutics Corp	$14.6B	$737 Million 1.16% of portfolio	2,089,392	Q4 2024 Reduced 3.06%
NVO Novo Nordisk A S	$205B	$715 Million 1.13% of portfolio	8,312,996	Q4 2024 Added 1.51%
VRTX Vertex Pharmaceuticals Inc	$123B	$563 Million 0.89% of portfolio	1,397,209	Q4 2024 Reduced 14.36%
EXEL Exelixis, Inc.	$12.5B	$509 Million 0.8% of portfolio	15,295,865	Q4 2024 Reduced 0.42%
CORT Corcept Therapeutics Inc	$6.49B	$312 Million 0.49% of portfolio	6,198,602	Q4 2024 Reduced 4.77%
INCY Incyte Corp	$16.3B	$282 Million 0.45% of portfolio	4,085,932	Q4 2024 Reduced 9.19%
REGN Regeneron Pharmaceuticals, Inc.	$74.9B	$176 Million 0.28% of portfolio	247,743	Q4 2024 Added 17.18%
JAZZ Jazz Pharmaceuticals PLC	$9B	$123 Million 0.19% of portfolio	1,001,874	Q4 2024 Reduced 4.58%
INVA Innoviva, Inc.	$1.25B	$73.9 Million 0.12% of portfolio	4,261,732	Q4 2024 Reduced 1.57%
ADMA Adma Biologics, Inc.	$3.22B	$64.7 Million 0.1% of portfolio	3,769,888	Q4 2024 Added 2.8%
CPRX Catalyst Pharmaceuticals, Inc.	$2.35B	$56.5 Million 0.09% of portfolio	2,706,116	Q4 2024 Added 7.13%
MDGL Madrigal Pharmaceuticals, Inc.	$5.84B	$49.6 Million 0.08% of portfolio	160,782	Q4 2024 Added 261.33%
MRNA Moderna, Inc.	$12.1B	$42 Million 0.07% of portfolio	1,010,758	Q4 2024 Added 225.74%
TVTX Travere Therapeutics, Inc.	$1.37B	$42 Million 0.07% of portfolio	2,409,514	Q4 2024 Added 28.51%
GMAB Genmab A/S	$14.9B	$40.2 Million 0.06% of portfolio	1,926,150	Q4 2024 Added 7.82%
LEGN Legend Biotech Corp	$5.86B	$29.5 Million 0.05% of portfolio	908,100	Q4 2024 Added 4,917.13%
PTCT Ptc Therapeutics, Inc.	$3.95B	$29.5 Million 0.05% of portfolio	653,100	Q4 2024 Added 21.35%
BMRN Biomarin Pharmaceutical Inc	$13.2B	$28.6 Million 0.05% of portfolio	435,871	Q4 2024 Added 4.06%
VCYT Veracyte, Inc.	$2.49B	$23.8 Million 0.04% of portfolio	600,700	Q4 2024 Added 1.08%
ACAD Acadia Pharmaceuticals Inc	$3.17B	$22.5 Million 0.04% of portfolio	1,226,533	Q4 2024 Added 204.2%
MRVI Maravai Lifesciences Holdings, Inc.	$424M	$21.6 Million 0.03% of portfolio	3,972,189	Q4 2024 Reduced 4.02%
FOLD Amicus Therapeutics, Inc.	$2.66B	$19.9 Million 0.03% of portfolio	2,108,616	Q4 2024 Added 174.1%
HRMY Harmony Biosciences Holdings, Inc.	$2B	$19.6 Million 0.03% of portfolio	568,671	Q4 2024 Added 15.44%
VNDA Vanda Pharmaceuticals Inc.	$269M	$18.5 Million 0.03% of portfolio	3,853,799	Q4 2024 Reduced 3.93%
MDXG Mimedx Group, Inc.	$954M	$17.4 Million 0.03% of portfolio	1,804,557	Q4 2024 Added 18.39%
NVAX Novavax Inc	$652M	$11.3 Million 0.02% of portfolio	1,407,530	Q4 2024 Reduced 31.83%
BPMC Blueprint Medicines Corp	$5.77B	$11 Million 0.02% of portfolio	126,300	Q4 2024 Reduced 27.62%
RARE Ultragenyx Pharmaceutical Inc.	$3.01B	$10.7 Million 0.02% of portfolio	254,700	Q4 2024 Added 39.87%
VIR Vir Biotechnology, Inc.	$1.11B	$9.08 Million 0.01% of portfolio	1,237,600	Q4 2024 Added 4.68%
CYTK Cytokinetics Inc	$4.33B	$9.04 Million 0.01% of portfolio	192,167	Q4 2024 Reduced 21.36%
SNDX Syndax Pharmaceuticals Inc	$885M	$9 Million 0.01% of portfolio	680,965	Q4 2024 New
APLS Apellis Pharmaceuticals, Inc.	$2.76B	$8.68 Million 0.01% of portfolio	271,913	Q4 2024 Reduced 26.97%
PTGX Protagonist Therapeutics, Inc	$1.85B	$8.54 Million 0.01% of portfolio	221,167	Q4 2024 Added 53.41%
GLPG Galapagos Nv	$1.72B	$8.14 Million 0.01% of portfolio	296,100	Q4 2024 Added 1.52%
IDYA Ideaya Biosciences, Inc.	$989M	$7.31 Million 0.01% of portfolio	284,267	Q4 2024 Added 66.86%
ABCL Ab Cellera Biologics Inc.	$739M	$7.29 Million 0.01% of portfolio	2,486,893	Q4 2024 Reduced 15.6%
IONS Ionis Pharmaceuticals Inc	$4.71B	$7.18 Million 0.01% of portfolio	205,514	Q4 2024 Added 7.87%
VRDN Viridian Therapeutics, Inc.\De	$619M	$7.12 Million 0.01% of portfolio	371,200	Q4 2024 Added 522.82%
XERS Xeris Biopharma Holdings, Inc.	$521M	$7.12 Million 0.01% of portfolio	2,098,840	Q4 2024 Added 31.28%
AKBA Akebia Therapeutics, Inc.	$340M	$7.11 Million 0.01% of portfolio	3,823,527	Q4 2024 Added 2.84%
ITOS I Teos Therapeutics, Inc.	$258M	$6.43 Million 0.01% of portfolio	837,200	Q4 2024 Added 56.08%
RLAY Relay Therapeutics, Inc.	$410M	$6.38 Million 0.01% of portfolio	1,549,190	Q4 2024 Added 130.85%
MNKD Mannkind Corp	$1.37B	$6.31 Million 0.01% of portfolio	981,645	Q4 2024 Added 50.66%
AUPH Aurinia Pharmaceuticals Inc.	$1.13B	$6.29 Million 0.01% of portfolio	700,900	Q4 2024 Added 44.01%
RNA Avidity Biosciences, Inc.	$1.6B	$6.14 Million 0.01% of portfolio	211,200	Q4 2024 Added 48.84%
PBYI Puma Biotechnology, Inc.	$163M	$5.35 Million 0.01% of portfolio	1,755,513	Q4 2024 Reduced 0.95%
KURA Kura Oncology, Inc.	$516M	$5.21 Million 0.01% of portfolio	597,810	Q4 2024 Added 463.39%
GERN Geron Corp	$665M	$5.14 Million 0.01% of portfolio	1,452,700	Q4 2024 New
ZLAB Zai Lab LTD	$3.39B	$4.92 Million 0.01% of portfolio	187,800	Q4 2024 Added 112.68%
VCEL Vericel Corp	$2.42B	$4.91 Million 0.01% of portfolio	89,500	Q4 2024 Added 11.46%

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Jim Simons

Jim Simons is the founder and chairman of Renaissance Technologies, a successful investment firm that uses quantitative approaches to investing. Simons is known for his expertise in mathematical modeling and has a reputation for being a skilled and successful investor. He has generated strong returns for his clients over the long term.

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