Manufacturers Life Insurance Company, The Biotechnology

Manufacturers Life Insurance Company, The

$109 Billion
Q4 2024

Stock List

Stock	Market Cap.	Holding Value (Reported)	# of Shares.	Last Trade	Trade History
REGN Regeneron Pharmaceuticals, Inc.	$68B	$254 Million 0.23% of portfolio	356,410	Q4 2024 Added 5.43%
VRTX Vertex Pharmaceuticals Inc	$124B	$220 Million 0.2% of portfolio	545,366	Q4 2024 Reduced 12.35%
MRNA Moderna, Inc.	$11.1B	$139 Million 0.13% of portfolio	3,341,924	Q4 2024 Added 8.72%
BBIO Bridge Bio Pharma, Inc.	$5.2B	$51.7 Million 0.05% of portfolio	1,885,794	Q4 2024 Added 23.08%
JAZZ Jazz Pharmaceuticals PLC	$7.78B	$43.5 Million 0.04% of portfolio	353,467	Q4 2024 Added 1.64%
UTHR United Therapeutics Corp	$14B	$43.5 Million 0.04% of portfolio	123,317	Q4 2024 Added 26.52%
ARGX Argenx Se	$32.7B	$38.2 Million 0.04% of portfolio	62,113	Q4 2024 Added 0.86%
ALNY Alnylam Pharmaceuticals, Inc.	$33.2B	$25.7 Million 0.02% of portfolio	109,102	Q4 2024 Reduced 42.99%
SRPT Sarepta Therapeutics, Inc.	$5.59B	$23.5 Million 0.02% of portfolio	193,652	Q4 2024 Added 158.97%
INSM Insmed Inc	$10.6B	$21.6 Million 0.02% of portfolio	313,181	Q4 2024 Added 8.72%
BPMC Blueprint Medicines Corp	$5.3B	$15.4 Million 0.01% of portfolio	176,484	Q4 2024 Added 17.66%
SWTX Spring Works Therapeutics, Inc.	$2.96B	$14.7 Million 0.01% of portfolio	407,683	Q4 2024 Added 42.77%
TECH Bio Techne Corp	$2.3B	$14.1 Million 0.01% of portfolio	196,405	Q4 2024 Reduced 1.47%
HALO Halozyme Therapeutics, Inc.	$8.89B	$13.6 Million 0.01% of portfolio	283,870	Q4 2024 Added 9.03%
PCVX Vaxcyte, Inc.	$2.24B	$13 Million 0.01% of portfolio	158,528	Q4 2024 Added 0.96%
INCY Incyte Corp	$13.5B	$12.8 Million 0.01% of portfolio	184,871	Q4 2024 Added 11.68%
ACAD Acadia Pharmaceuticals Inc	$2.76B	$11.5 Million 0.01% of portfolio	628,016	Q4 2024 Added 51.96%
ASND Ascendis Pharma A/S	$8.7B	$11.4 Million 0.01% of portfolio	82,955	Q4 2024 Added 16.34%
BGNE Bei Gene, Ltd.	$23.5B	$11.1 Million 0.01% of portfolio	59,831	Q4 2024 Added 4.26%
RVMD Revolution Medicines, Inc.	$3.28B	$10.4 Million 0.01% of portfolio	237,539	Q4 2024 Added 11.6%
BMRN Biomarin Pharmaceutical Inc	$13.1B	$10.1 Million 0.01% of portfolio	154,296	Q4 2024 Reduced 3.51%
IONS Ionis Pharmaceuticals Inc	$4.28B	$10 Million 0.01% of portfolio	286,279	Q4 2024 Reduced 7.34%
SRRK Scholar Rock Holding Corp	$1.7B	$9.19 Million 0.01% of portfolio	212,727	Q4 2024 Reduced 1.78%
RARE Ultragenyx Pharmaceutical Inc.	$2.65B	$9.11 Million 0.01% of portfolio	216,587	Q4 2024 Reduced 9.02%
CYTK Cytokinetics Inc	$4.07B	$8.87 Million 0.01% of portfolio	188,538	Q4 2024 Reduced 12.24%
SMMT Summit Therapeutics Inc.	$4.09B	$8.51 Million 0.01% of portfolio	476,814	Q4 2024 Added 61.29%
EXEL Exelixis, Inc.	$11.9B	$7.9 Million 0.01% of portfolio	237,351	Q4 2024 Reduced 1.53%
RNA Avidity Biosciences, Inc.	$1.65B	$7.69 Million 0.01% of portfolio	264,305	Q4 2024 Added 2.66%
CRNX Crinetics Pharmaceuticals, Inc.	$1.8B	$7.62 Million 0.01% of portfolio	148,956	Q4 2024 Added 11.09%
MLTX Moon Lake Immunotherapeutics	$1.47B	$7.58 Million 0.01% of portfolio	142,702	Q4 2024 Added 20.8%
ACLX Arcellx, Inc.	$2.98B	$7.49 Million 0.01% of portfolio	98,314	Q4 2024 Added 15.88%
MDGL Madrigal Pharmaceuticals, Inc.	$5.61B	$7.43 Million 0.01% of portfolio	24,080	Q4 2024 Reduced 19.62%
KYMR Kymera Therapeutics, Inc.	$1.62B	$5.93 Million 0.01% of portfolio	147,296	Q4 2024 Added 14.84%
VRNA Verona Pharma PLC	$3.82B	$5.89 Million 0.01% of portfolio	126,730	Q4 2024 Added 20.51%
KRYS Krystal Biotech, Inc.	$4.72B	$5.52 Million 0.01% of portfolio	35,206	Q4 2024 Added 12.75%
VERA Vera Therapeutics, Inc.	$720M	$5.43 Million 0.0% of portfolio	128,380	Q4 2024 Added 26.03%
CNTA Centessa Pharmaceuticals PLC	$1.38B	$5.32 Million 0.0% of portfolio	317,329	Q4 2024 Added 19.76%
PTGX Protagonist Therapeutics, Inc	$2.4B	$4.8 Million 0.0% of portfolio	124,341	Q4 2024 Added 7.41%
DNLI Denali Therapeutics Inc.	$1.98B	$4.25 Million 0.0% of portfolio	208,521	Q4 2024 Added 0.82%
ZLAB Zai Lab LTD	$3.65B	$4.2 Million 0.0% of portfolio	160,378	Q4 2024 Added 32.45%
AGIO Agios Pharmaceuticals, Inc.	$1.66B	$4.01 Million 0.0% of portfolio	122,094	Q4 2024 Reduced 14.88%
ROIV Roivant Sciences Ltd.	$7.31B	$4 Million 0.0% of portfolio	338,013	Q4 2024 Reduced 5.21%
RPRX Royalty Pharma PLC	$13.6B	$3.88 Million 0.0% of portfolio	151,954	Q4 2024 Reduced 0.05%
NUVL Nuvalent, Inc.	$3.14B	$3.79 Million 0.0% of portfolio	48,372	Q4 2024 Added 5.84%
NVO Novo Nordisk A S	$157B	$3.63 Million 0.0% of portfolio	42,251	Q4 2024 Reduced 58.28%
BEAM Beam Therapeutics Inc.	$1.37B	$3.56 Million 0.0% of portfolio	143,502	Q4 2024 Reduced 1.61%
AKRO Akero Therapeutics, Inc.	$1.98B	$3.47 Million 0.0% of portfolio	124,592	Q4 2024 Added 29.05%
JANX Janux Therapeutics, Inc.	$1.21B	$3.4 Million 0.0% of portfolio	63,512	Q4 2024 Added 107.59%
IMCR Immunocore Holdings PLC	$1.3B	$3.37 Million 0.0% of portfolio	114,151	Q4 2024 Added 6.29%
RYTM Rhythm Pharmaceuticals, Inc.	$3.05B	$3.35 Million 0.0% of portfolio	59,969	Q4 2024 Added 23.13%

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