Opaleye Management Inc. has filed its 13F form on November 14, 2025 for Q3 2025 where it was disclosed a total value porftolio of $600 Million distributed in 43 stocks.

Among their holdings, we can observe that their the top five positions include companies like: Harrow Health, Inc. with a value of $184M, Eton Pharmaceuticals, Inc. with a value of $62.4M, Liquidia Corp with a value of $60M, Rhythm Pharmaceuticals, Inc. with a value of $46.6M, and Immunome Inc. with a value of $36.9M.

Examining the 13F form we can see an increase of $182M in the current position value, from $418M to 600M.

Opaleye Management Inc. is based out at Boston, MA

Below you can find more details about Opaleye Management Inc. portfolio as well as his latest detailed transactions.

Portfolio value $600 Million
Healthcare: $600 Million

Stock Holdings Table

Stock Market Cap. Holding Value (Reported) # of Shares. Last Trade Trade History

Summary

  • Portfolio
  • No. of Stocks 43
  • Current Value $600 Million
  • Prior Value $418 Million
  • Filing
  • Period Q3 2025
  • Filing Date November 14, 2025
  • Form Type 13F-HR
  • Activity in Q3 2025
  • New Purchases 11 stocks
  • Additional Purchases 9 stocks
  • Sold out of 0 stocks
  • Reduced holdings in 11 stocks
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