Jim Simons Biotechnology

Renaissance Technologies LLC

$63.4 Billion
Q4 2024

Stock List

Stock	Market Cap.	Holding Value (Reported)	# of Shares.	Last Trade
GLSI Greenwich Life Sciences, Inc.	$115M	$254,000 0.0% of portfolio	22,700	Q4 2024 Reduced 30.15%
ATNM Actinium Pharmaceuticals, Inc.	$30.5M	$239,000 0.0% of portfolio	190,400	Q4 2024 Added 49.92%
FHTX Foghorn Therapeutics Inc.	$158M	$225,000 0.0% of portfolio	47,736	Q4 2024 Added 89.16%
AIKI A Ikido Pharma Inc.	$20.8M	$214,000 0.0% of portfolio	56,326	Q4 2024 Added 20.03%
GHRS Gh Research PLC	$473M	$212,000 0.0% of portfolio	30,300	Q4 2024 Reduced 0.33%
EQ Equillium, Inc.	$16.1M	$206,000 0.0% of portfolio	261,400	Q4 2024 Reduced 18.61%
RGLS Regulus Therapeutics Inc.	$30.1M	$185,000 0.0% of portfolio	117,100	Q4 2024 Added 20.47%
ENLV Enlivex Therapeutics Ltd.	$15.8M	$184,000 0.0% of portfolio	158,992	Q4 2024 Added 112.59%
PROK Prokidney Corp Ord Shs Cl A(Cy	$48.6M	$177,000 0.0% of portfolio	105,200	Q4 2024 Added 127.71%
BOLT Bolt Biotherapeutics, Inc.	$13.2M	$166,000 0.0% of portfolio	302,039	Q4 2024 Added 2.72%
SPRB Spruce Biosciences, Inc.	$2.83M	$166,000 0.0% of portfolio	405,900	Q4 2024 Reduced 33.43%
PDSB Pds Biotechnology Corp	$30.7M	$163,000 0.0% of portfolio	100,000	Q4 2024 Added 331.03%
CNTB Connect Biopharma Holdings LTD	$40.7M	$161,000 0.0% of portfolio	134,697	Q4 2024 Reduced 23.25%
ALVR Allovir, Inc.	$913M	$159,000 0.0% of portfolio	379,563	Q4 2024 Reduced 51.14%
ARQT Arcutis Biotherapeutics, Inc.	$783M	$154,000 0.0% of portfolio	11,099	Q4 2024 Reduced 94.22%
OCUP Ocuphire Pharma, Inc.	$20.2M	$142,000 0.0% of portfolio	145,509	Q4 2024 Added 106.08%
ENTX Entera Bio Ltd.	$51.6M	$128,000 0.0% of portfolio	61,800	Q4 2024 Added 0.98%
DRTS Alpha Tau Medical Ltd.	$177M	$127,000 0.0% of portfolio	41,000	Q4 2024 Added 188.73%
ATHA Athira Pharma, Inc.	$9.08M	$122,000 0.0% of portfolio	207,300	Q4 2024 Reduced 54.22%
VACC Vaccitech PLC	$127M	$119,000 0.0% of portfolio	35,100	Q4 2024 Added 25.81%
AVTE Aerovate Therapeutics, Inc.	$67.2M	$118,000 0.0% of portfolio	44,600	Q4 2024 Added 149.16%
IOBT Io Biotech, Inc.	$24.8M	$109,000 0.0% of portfolio	118,800	Q4 2024 Added 22.47%
OVID Ovid Therapeutics Inc.	$20.4M	$100,000 0.0% of portfolio	107,700	Q4 2024 Added 142.02%
RNXT Renovo Rx, Inc.	$9.25M	$92,000 0.0% of portfolio	64,900	Q4 2024 New
RLMD Relmada Therapeutics, Inc.	$8.3M	$85,000 0.0% of portfolio	164,513	Q4 2024 Added 535.48%
HOWL Werewolf Therapeutics, Inc.	$27.2M	$84,000 0.0% of portfolio	56,900	Q4 2024 Reduced 62.61%
SNSE Sensei Biotherapeutics, Inc.	$12.6M	$78,000 0.0% of portfolio	156,800	Q4 2024 Reduced 27.26%
PMCB Pharma Cyte Biotech, Inc.	$24.7M	$76,000 0.0% of portfolio	49,300	Q4 2024 Reduced 0.8%
ARMP Armata Pharmaceuticals, Inc.	$44.5M	$74,000 0.0% of portfolio	40,291	Q4 2024 Reduced 13.35%
CGTX Cognition Therapeutics Inc	$8.4M	$68,000 0.0% of portfolio	91,100	Q4 2024 Added 2.71%
INKT Mi Nk Therapeutics, Inc.	$245M	$68,000 0.0% of portfolio	101,707	Q4 2024 Reduced 4.67%
TNGX Tango Therapeutics, Inc.	$114M	$66,000 0.0% of portfolio	21,500	Q4 2024 New
IMAB I Mab	$70.6M	$54,000 0.0% of portfolio	63,800	Q3 2023 Reduced 74.1%
AIM Aim Immuno Tech Inc.	$1.92M	$52,000 0.0% of portfolio	260,479	Q4 2024 Added 7.1%
VIRX Viracta Therapeutics, Inc.	$751K	$45,000 0.0% of portfolio	286,395	Q4 2024 Added 16.71%
DYAI Dyadic International Inc	$35M	$43,000 0.0% of portfolio	24,900	Q4 2024 Added 8.26%
CLGN Coll Plant Biotechnologies LTD	$26.8M	$38,000 0.0% of portfolio	10,600	Q4 2024 New
LXRX Lexicon Pharmaceuticals, Inc.	$96.3M	$37,000 0.0% of portfolio	51,141	Q4 2024 New
ANIX Anixa Biosciences Inc	$83.4M	$36,000 0.0% of portfolio	14,573	Q4 2024 Added 36.54%
STTK Shattuck Labs, Inc.	$32.6M	$34,000 0.0% of portfolio	28,100	Q4 2024 Reduced 88.79%
SILO Silo Pharma, Inc.	$3.36M	$33,000 0.0% of portfolio	37,500	Q4 2024 Reduced 83.48%
TCRX T Scan Therapeutics, Inc.	$27.3M	$32,000 0.0% of portfolio	10,600	Q4 2024 Reduced 85.68%
IPA Immuno Precise Antibodies Ltd.	$10.9M	$31,000 0.0% of portfolio	78,200	Q4 2024 Added 29.68%
BTAI Bio Xcel Therapeutics, Inc.	$48.8M	$28,000 0.0% of portfolio	77,900	Q4 2024 Reduced 40.02%
INDP Indaptus Therapeutics, Inc.	$3.96M	$23,000 0.0% of portfolio	27,700	Q4 2024 Added 2.21%
BYSI Beyond Spring Inc.	$51M	$18,000 0.0% of portfolio	11,600	Q4 2024 Reduced 0.85%
OMGA Omega Therapeutics, Inc.	$957K	$13,000 0.0% of portfolio	17,820	Q4 2024 Reduced 96.25%
ACXP Acurx Pharmaceuticals, Inc.	$4.28M	$11,000 0.0% of portfolio	14,674	Q4 2024 New
ONVO Organovo Holdings, Inc.	$15M	$11,000 0.0% of portfolio	31,630	Q4 2024 Reduced 28.16%
GLYC Glycomimetics Inc	$11.5M	$10,000 0.0% of portfolio	41,153	Q4 2024 Reduced 94.73%

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Jim Simons

Jim Simons is the founder and chairman of Renaissance Technologies, a successful investment firm that uses quantitative approaches to investing. Simons is known for his expertise in mathematical modeling and has a reputation for being a skilled and successful investor. He has generated strong returns for his clients over the long term.

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