Sio Capital Management, LLC Portfolio Holdings

Sio Capital Management, LLC

  • $289 Million
  • Q3 2025

Sio Capital Management, LLC has filed its 13F form on November 13, 2025 for Q3 2025 where it was disclosed a total value porftolio of $289 Million distributed in 51 stocks.

Among their holdings, we can observe that their the top five positions include companies like: Maximus, Inc. with a value of $50.9M, Celcuity Inc. with a value of $38.7M, Sanofi with a value of $26.6M, Alkermes Plc. with a value of $20.2M, and Merck & Co., Inc. with a value of $14.9M.

Examining the 13F form we can see an increase of $79.2M in the current position value, from $209M to 289M.

Sio Capital Management, LLC is based out at New York, NY

Below you can find more details about Sio Capital Management, LLC portfolio as well as his latest detailed transactions.

Portfolio value $289 Million
Healthcare: $238 Million
Industrials: $50.9 Million

Stock Holdings Table

Stock Market Cap. Holding Value (Reported) # of Shares. Last Trade Trade History
$4.83B
$50.9 Million 17.66% of portfolio
557,615
Q3 2025 Added 1.74%
$1.38B
$38.7 Million 13.4% of portfolio
786,526
Q3 2025 New
$130B
$26.6 Million 9.21% of portfolio
562,703
Q3 2025 Added 200.11%
$4.77B
$20.2 Million 7.02% of portfolio
674,840
Q3 2025 New
$235B
$14.9 Million 5.16% of portfolio
177,300
Q3 2025 Added 1.93%
$9.72B
$14.5 Million 5.04% of portfolio
219,207
Q3 2025 New
$20.6B
$13.8 Million 4.79% of portfolio
387,600
Q3 2025 Added 47.66%
$10.2B
$12.2 Million 4.23% of portfolio
225,114
Q2 2025 Added 59.5%
$3.77B
$9.65 Million 3.35% of portfolio
198,035
Q3 2025 New
$288M
$8.37 Million 2.9% of portfolio
1,498,095
Q3 2025 Added 58.11%
$328M
$8.26 Million 2.86% of portfolio
683,819
Q3 2025 New
$2.34B
$7.28 Million 2.52% of portfolio
174,841
Q3 2025 New
$652M
$7.2 Million 2.5% of portfolio
514,947
Q3 2025 Reduced 36.45%
$1.19B
$5.35 Million 1.85% of portfolio
413,829
Q3 2025 New
$1.46B
$5.1 Million 1.77% of portfolio
55,723
Q3 2025 Reduced 50.65%
$1.44B
$4.98 Million 1.73% of portfolio
307,181
Q3 2025 Reduced 43.09%
$351M
$4.83 Million 1.67% of portfolio
320,307
Q3 2025 New
$156M
$4.38 Million 1.52% of portfolio
2,075,139
Q2 2025 Added 1.0%
$63M
$3.69 Million 1.28% of portfolio
2,636,548
Q3 2025 Reduced 29.42%
$1.54B
$3.38 Million 1.17% of portfolio
124,230
Q2 2025 Added 1.0%
$315M
$2.99 Million 1.03% of portfolio
1,369,748
Q2 2025 Added 1.0%
$747M
$2.73 Million 0.95% of portfolio
478,343
Q2 2025 Added 1.0%
$495M
$2.56 Million 0.89% of portfolio
726,851
Q2 2025 Added 1.0%
$523M
$2.58 Million 0.89% of portfolio
829,178
Q3 2025 Reduced 36.61%
$11.2M
$2.1 Million 0.73% of portfolio
2,360,635
Q3 2025 Reduced 33.01%
$92.2M
$1.83 Million 0.63% of portfolio
1,427,495
Q3 2025 Reduced 36.04%
$18.5M
$1.3 Million 0.45% of portfolio
1,341,636
Q2 2025 Added 1.0%
$2.91B
$1.02 Million 0.35% of portfolio
2,315,749
Q3 2025 Reduced 52.28%
$18.8M
$935,000 0.32% of portfolio
636,300
Q2 2025 Added 1.0%
$195M
$600,000 0.21% of portfolio
122,889
Q2 2025 Added 1.0%
$5.78M
$557,000 0.19% of portfolio
785,824
Q2 2025 Added 211.85%
$846M
$76,000 0.03% of portfolio
10,100
Q2 2025 Added 1.0%
Septerna Inc
-
$0 0.0% of portfolio
-
Q3 2025 Reduced 67.63%
Shoulder Innovations Inc
-
$0 0.0% of portfolio
-
Q3 2025 New
Avalo Therapeutics Inc
-
$0 0.0% of portfolio
-
Q2 2025 Added 1.0%
Bridgebio Oncology Therapeut
-
$0 0.0% of portfolio
-
Q3 2025 New
Boundless Bio Inc
-
$0 0.0% of portfolio
-
Q2 2025 Added 1.0%
Aprea Therapeutics Inc
-
$0 0.0% of portfolio
-
Q3 2025 Reduced 59.83%
Anteris Technologies Global
-
$0 0.0% of portfolio
-
Q3 2025 Reduced 3.61%
Bright Minds Biosciences Inc
-
$0 0.0% of portfolio
-
Q3 2025 Reduced 62.77%
Aligos Therapeutics Inc
-
$0 0.0% of portfolio
-
Q2 2025 Added 85.89%
Nextcure Inc
-
$0 0.0% of portfolio
-
Q3 2025 New
Kenvue Inc
-
$0 0.0% of portfolio
-
Q3 2025 New
Nyxoah S A
-
$0 0.0% of portfolio
-
Q1 2024 Reduced 74.59%
$0
$13,000 0.0% of portfolio
49,998
Q1 2023 New
Gsk PLC
-
$0 0.0% of portfolio
-
Q3 2025 New
Rapport Therapeutics Inc
-
$0 0.0% of portfolio
-
Q3 2025 New
Disc Medicine Inc
-
$0 0.0% of portfolio
-
Q2 2025 Added 287.41%
Dianthus Therapeutics Inc
-
$0 0.0% of portfolio
-
Q3 2025 Added 144.74%

Summary

  • Portfolio
  • No. of Stocks 51
  • Current Value $289 Million
  • Prior Value $209 Million
  • Filing
  • Period Q3 2025
  • Filing Date November 13, 2025
  • Form Type 13F-HR
  • Activity in Q3 2025
  • New Purchases 15 stocks
  • Additional Purchases 6 stocks
  • Sold out of 0 stocks
  • Reduced holdings in 12 stocks
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