Siren, L.L.C. Portfolio Holdings

Siren, L.L.C.

  • $1.76 Trillion
  • Q1 2025

Siren, L.L.C. has filed its 13F form on May 14, 2025 for Q1 2025 where it was disclosed a total value porftolio of $1.76 Trillion distributed in 117 stocks.

Among their holdings, we can observe that their the top five positions include companies like: Scholar Rock Holding Corp with a value of $297B, Bei Gene, Ltd. with a value of $136B, Kymera Therapeutics, Inc. with a value of $88.7B, Blueprint Medicines Corp with a value of $64.3B, and Crinetics Pharmaceuticals, Inc. with a value of $56.6B.

Examining the 13F form we can see an decrease of $507B in the current position value, from $2.26T to 1.76T.

Siren, L.L.C. is based out at New York, NY

Below you can find more details about Siren, L.L.C. portfolio as well as his latest detailed transactions.

Portfolio value $1.76 Trillion
Technology: $90.5 Billion
Communication Services: $49.6 Billion
Consumer Cyclical: $21.5 Billion
Financial Services: $4.29 Billion
Consumer Defensive: $3.8 Billion
Real Estate: $2.11 Billion
Industrials: $853 Million
Energy: $494 Million
Other: $162 Million

Stock Holdings Table

Stock Market Cap. Holding Value (Reported) # of Shares. Last Trade Trade History
Spyre Therapeutics Inc
-
$5.95 Billion 0.34% of portfolio
-
Q1 2025 Reduced 1.44%
$181M
$5.73 Billion 0.33% of portfolio
5,208,968
Q4 2024 Reduced 60.78%
$377M
$5.62 Billion 0.32% of portfolio
1,007,575
Q3 2024 New
Upstream Bio Inc
-
$4.83 Billion 0.27% of portfolio
-
Q1 2025 Reduced 1.44%
$37.5B
$4.71 Billion 0.27% of portfolio
47,425
Q1 2025 Added 55.88%
$456B
$4.82 Billion 0.27% of portfolio
44,432
Q1 2025 Reduced 9.2%
$1.27T
$4.73 Billion 0.27% of portfolio
28,500
Q1 2025 Added 90.0%
Neumora Therapeutics Inc
-
$4.36 Billion 0.25% of portfolio
-
Q1 2025 Reduced 0.86%
$4.08B
$4.21 Billion 0.24% of portfolio
131,616
Q1 2025 Added 9.57%
$13.4B
$4.14 Billion 0.24% of portfolio
87,729
Q1 2025 Added 6.04%
Metsera Inc
-
$4.08 Billion 0.23% of portfolio
-
Q1 2025 New
$232B
$3.92 Billion 0.22% of portfolio
14,600
Q1 2025 New
$220M
$3.94 Billion 0.22% of portfolio
591,263
Q1 2025 Reduced 1.46%
Rapport Therapeutics Inc
-
$3.8 Billion 0.22% of portfolio
-
Q1 2025 Reduced 1.49%
$7.87B
$3.8 Billion 0.22% of portfolio
79,500
Q1 2025 Added 16.06%
$8.57B
$3.75 Billion 0.21% of portfolio
170,000
Q4 2024 Reduced 66.0%
$35.9M
$3.71 Billion 0.21% of portfolio
2,082,000
Q1 2025 New
$595M
$3.51 Billion 0.2% of portfolio
2,565,342
Q1 2025 Reduced 1.48%
$228M
$3.5 Billion 0.2% of portfolio
1,967,064
Q1 2025 Reduced 1.2%
Instil Bio Inc
-
$3.54 Billion 0.2% of portfolio
-
Q1 2025 Added 5.98%
Sionna Therapeutics Inc
-
$3.4 Billion 0.19% of portfolio
-
Q1 2025 New
Nebius Group Nv
-
$2.96 Billion 0.17% of portfolio
-
Q1 2025 Added 16.67%
$203M
$2.63 Billion 0.15% of portfolio
720,720
Q3 2024 New
$29.8B
$2.45 Billion 0.14% of portfolio
7,500
Q1 2025 New
Reddit Inc
-
$2.47 Billion 0.14% of portfolio
-
Q1 2025 New
$37.4M
$2.34 Billion 0.13% of portfolio
690,170
Q1 2025 New
Sagimet Biosciences Inc
-
$2.36 Billion 0.13% of portfolio
-
Q3 2024 New
$1.08T
$2.33 Billion 0.13% of portfolio
9,000
Q1 2025 New
$66.3B
$2.27 Billion 0.13% of portfolio
36,808
Q1 2025 Added 636.16%
Kalaris Therapeutics Inc
-
$2.27 Billion 0.13% of portfolio
-
Q1 2025 New
Lexeo Therapeutics Inc
-
$2.09 Billion 0.12% of portfolio
-
Q3 2024 New
$155M
$2.06 Billion 0.12% of portfolio
1,552,183
Q1 2025 Reduced 1.45%
$22B
$2.11 Billion 0.12% of portfolio
105,000
Q1 2025 Added 75.0%
$173B
$2.15 Billion 0.12% of portfolio
14,000
Q1 2025 Reduced 6.67%
$52.5B
$1.96 Billion 0.11% of portfolio
11,500
Q1 2025 Added 91.67%
Sail Point Inc
-
$1.78 Billion 0.1% of portfolio
-
Q1 2025 New
$200M
$1.62 Billion 0.09% of portfolio
3,516,214
Q1 2025 Added 1,006.84%
Standard Aero, Inc.
-
$1.51 Billion 0.09% of portfolio
-
Q1 2025 New
$87.2M
$1.62 Billion 0.09% of portfolio
1,046,517
Q3 2024 New
Tourmaline Bio Inc
-
$1.39 Billion 0.08% of portfolio
-
Q3 2024 New
$3.53B
$1.33 Billion 0.08% of portfolio
17,500
Q1 2025 Added 75.0%
Bioage Labs Inc
-
$1.44 Billion 0.08% of portfolio
-
Q1 2025 Reduced 1.44%
$4.19B
$1.15 Billion 0.07% of portfolio
16,500
Q1 2025 New
$4.12B
$1.31 Billion 0.07% of portfolio
28,500
Q1 2025 New
$239M
$1.2 Billion 0.07% of portfolio
2,968,925
Q1 2025 Reduced 0.46%
$78.6B
$1.31 Billion 0.07% of portfolio
20,000
Q1 2025 Added 33.33%
$321M
$1.17 Billion 0.07% of portfolio
125,000
Q1 2025 Added 257.14%
$5.9B
$873 Million 0.05% of portfolio
50,000
Q1 2025 New
$94.4B
$952 Million 0.05% of portfolio
15,000
Q1 2025 New

Summary

  • Portfolio
  • No. of Stocks 117
  • Current Value $1.76 Trillion
  • Prior Value $2.26 Trillion
  • Filing
  • Period Q1 2025
  • Filing Date May 14, 2025
  • Form Type 13F-HR
  • Activity in Q1 2025
  • New Purchases 24 stocks
  • Additional Purchases 28 stocks
  • Sold out of 0 stocks
  • Reduced holdings in 41 stocks
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