Sr One Capital Management, LP Portfolio Holdings

Sr One Capital Management, LP

  • $435 Million
  • Q3 2025

Sr One Capital Management, LP has filed its 13F form on November 12, 2025 for Q3 2025 where it was disclosed a total value porftolio of $435 Million distributed in 12 stocks.

Among their holdings, we can observe that their the top five positions include companies like: Arcellx, Inc. with a value of $193M, Crispr Therapeutics Ag with a value of $132M, Oric Pharmaceuticals, Inc. with a value of $53.9M, Design Therapeutics, Inc. with a value of $49.1M, and Nkarta, Inc. with a value of $6.9M.

Examining the 13F form we can see an increase of $156M in the current position value, from $279M to 435M.

Below you can find more details about Sr One Capital Management, LP portfolio as well as his latest detailed transactions.

Portfolio value $435 Million
Healthcare: $435 Million

Stock Holdings Table

Stock Market Cap. Holding Value (Reported) # of Shares. Last Trade Trade History
$3.94B
$193 Million 44.32% of portfolio
2,346,630
Q1 2024 Reduced 25.42%
$4.32B
$132 Million 30.4% of portfolio
2,038,763
Q3 2025 Added 94.36%
$518M
$53.9 Million 12.39% of portfolio
4,514,929
Q2 2025 New
$411M
$49.1 Million 11.31% of portfolio
6,526,476
Q4 2022 Added 16.0%
$91M
$6.9 Million 1.59% of portfolio
3,333,333
Q1 2024 Added 150.0%
Oruka Therapeutics, Inc
-
$0 0.0% of portfolio
-
Q4 2024 Added 14.65%
Oculis Holding Ag
-
$0 0.0% of portfolio
-
Q1 2025 New
Mineralys Therapeutics Inc.
-
$0 0.0% of portfolio
-
Q3 2025 Reduced 32.42%
En Gene Holdings Inc.
-
$0 0.0% of portfolio
-
Q3 2024 Added 49.55%
$0
$0 0.0% of portfolio
4,012,903
Q1 2023 Added 33.33%
Alumis Inc.
-
$0 0.0% of portfolio
-
Q2 2024 New
Zenas Bio Pharma, Inc
-
$0 0.0% of portfolio
-
Q3 2024 New

Summary

  • Portfolio
  • No. of Stocks 12
  • Current Value $435 Million
  • Prior Value $279 Million
  • Filing
  • Period Q3 2025
  • Filing Date November 12, 2025
  • Form Type 13F-HR
  • Activity in Q3 2025
  • New Purchases 0 stocks
  • Additional Purchases 1 stocks
  • Sold out of 0 stocks
  • Reduced holdings in 1 stocks
Track This Portfolio

Track Sr One Capital Management, LP Portfolio

Follow Sr One Capital Management, LP and customize your updates to receive the information that matters most to you.

Portfolio Update

Get notified when there are updates to the investment portfolio of Sr One Capital Management, LP, based on Form 13F filings with the SEC.

News

Stay updated on Sr One Capital Management, LP with notifications on news.

Choose your preferred platform and Sign Up 👇 Telegram Email