State Of Wisconsin Investment Board Biotechnology

State Of Wisconsin Investment Board

$36.9 Billion
Q4 2024

Stock List

Stock	Market Cap.	Holding Value (Reported)	# of Shares.	Last Trade	Trade History
VRTX Vertex Pharmaceuticals Inc	$126B	$61.3 Million 0.17% of portfolio	152,240	Q4 2024 Reduced 1.26%
REGN Regeneron Pharmaceuticals, Inc.	$62.8B	$42.7 Million 0.12% of portfolio	59,893	Q4 2024 Reduced 6.67%
ALNY Alnylam Pharmaceuticals, Inc.	$29.1B	$18.4 Million 0.05% of portfolio	78,375	Q4 2024 Reduced 0.91%
INCY Incyte Corp	$12.8B	$15.5 Million 0.04% of portfolio	223,825	Q4 2024 Added 50.54%
UTHR United Therapeutics Corp	$13.3B	$12.9 Million 0.04% of portfolio	36,621	Q4 2024 Added 9.64%
TECH Bio Techne Corp	$1.93B	$11.2 Million 0.03% of portfolio	154,938	Q4 2024 Added 20.74%
INSM Insmed Inc	$9.65B	$8.43 Million 0.02% of portfolio	122,111	Q4 2024 Added 11.7%
BMRN Biomarin Pharmaceutical Inc	$11.4B	$8.31 Million 0.02% of portfolio	126,438	Q4 2024 Reduced 10.26%
MRNA Moderna, Inc.	$10.1B	$7.65 Million 0.02% of portfolio	183,926	Q4 2024 Reduced 12.4%
SRPT Sarepta Therapeutics, Inc.	$5.19B	$7.55 Million 0.02% of portfolio	62,058	Q4 2024 Added 7.26%
PCVX Vaxcyte, Inc.	$1.85B	$7.26 Million 0.02% of portfolio	88,705	Q4 2024 Added 22.66%
MRUS Merus N.V.	$1.98B	$6.64 Million 0.02% of portfolio	157,865	Q4 2024 Reduced 5.2%
EXEL Exelixis, Inc.	$11.7B	$6.47 Million 0.02% of portfolio	194,348	Q4 2024 Reduced 4.88%
TGTX Tg Therapeutics, Inc.	$5.37B	$5.87 Million 0.02% of portfolio	195,164	Q4 2024 Added 1.13%
RPRX Royalty Pharma PLC	$14.1B	$5.36 Million 0.01% of portfolio	209,999	Q4 2024 Reduced 3.21%
JAZZ Jazz Pharmaceuticals PLC	$6.48B	$4.95 Million 0.01% of portfolio	40,208	Q4 2024 Reduced 3.22%
ADMA Adma Biologics, Inc.	$3.86B	$4.38 Million 0.01% of portfolio	255,683	Q4 2024 Added 23.33%
ACAD Acadia Pharmaceuticals Inc	$2.32B	$4.38 Million 0.01% of portfolio	238,744	Q4 2024 Added 0.08%
HALO Halozyme Therapeutics, Inc.	$8.11B	$4.05 Million 0.01% of portfolio	84,717	Q4 2024 Reduced 2.87%
CRNX Crinetics Pharmaceuticals, Inc.	$1.68B	$3.84 Million 0.01% of portfolio	75,103	Q4 2024 Added 14.85%
KRYS Krystal Biotech, Inc.	$4.33B	$3.84 Million 0.01% of portfolio	24,502	Q4 2024 Added 6.22%
CORT Corcept Therapeutics Inc	$6.93B	$3.81 Million 0.01% of portfolio	75,700	Q4 2024 Reduced 30.73%
CPRX Catalyst Pharmaceuticals, Inc.	$2.26B	$3.79 Million 0.01% of portfolio	181,777	Q4 2024 Reduced 10.66%
XENE Xenon Pharmaceuticals Inc.	$2.29B	$3.79 Million 0.01% of portfolio	96,584	Q4 2024 Reduced 4.36%
PTCT Ptc Therapeutics, Inc.	$3.45B	$3.76 Million 0.01% of portfolio	83,273	Q4 2024 Added 70.43%
BPMC Blueprint Medicines Corp	$4.98B	$3.67 Million 0.01% of portfolio	42,057	Q4 2024 Reduced 11.13%
IONS Ionis Pharmaceuticals Inc	$4.12B	$3.54 Million 0.01% of portfolio	101,231	Q4 2024 Added 17.48%
RVMD Revolution Medicines, Inc.	$3.23B	$3.5 Million 0.01% of portfolio	79,985	Q4 2024 Added 2.74%
CYTK Cytokinetics Inc	$3.56B	$3.46 Million 0.01% of portfolio	73,626	Q4 2024 Reduced 13.63%
VKTX Viking Therapeutics, Inc.	$1.82B	$3.3 Million 0.01% of portfolio	81,964	Q4 2024 Added 9.68%
MNKD Mannkind Corp	$1.18B	$3.3 Million 0.01% of portfolio	512,472	Q4 2024 Added 42.13%
BCRX Biocryst Pharmaceuticals Inc	$1.45B	$3.21 Million 0.01% of portfolio	427,282	Q4 2024 Added 132.31%
VCEL Vericel Corp	$1.86B	$3.1 Million 0.01% of portfolio	56,531	Q4 2024 Reduced 26.97%
RARE Ultragenyx Pharmaceutical Inc.	$2.52B	$2.88 Million 0.01% of portfolio	68,345	Q4 2024 Added 4.72%
ROIV Roivant Sciences Ltd.	$7.34B	$2.87 Million 0.01% of portfolio	242,221	Q4 2024 Reduced 2.82%
NUVL Nuvalent, Inc.	$3.01B	$2.82 Million 0.01% of portfolio	36,005	Q4 2024 Added 33.89%
MIRM Mirum Pharmaceuticals, Inc.	$1.41B	$2.77 Million 0.01% of portfolio	66,944	Q4 2024 Added 34.6%
RNA Avidity Biosciences, Inc.	$1.49B	$2.7 Million 0.01% of portfolio	92,760	Q4 2024 Added 28.18%
SWTX Spring Works Therapeutics, Inc.	$2.53B	$2.7 Million 0.01% of portfolio	74,654	Q4 2024 Added 25.06%
MDGL Madrigal Pharmaceuticals, Inc.	$5.18B	$2.68 Million 0.01% of portfolio	8,690	Q4 2024 Added 0.77%
ACLX Arcellx, Inc.	$2.77B	$2.61 Million 0.01% of portfolio	34,332	Q4 2024 Added 13.53%
FOLD Amicus Therapeutics, Inc.	$1.94B	$2.61 Million 0.01% of portfolio	277,170	Q4 2024 Reduced 15.06%
APLS Apellis Pharmaceuticals, Inc.	$1.91B	$2.56 Million 0.01% of portfolio	80,382	Q4 2024 Reduced 0.81%
AUPH Aurinia Pharmaceuticals Inc.	$1.12B	$2.53 Million 0.01% of portfolio	282,012	Q4 2024 Reduced 23.78%
HRMY Harmony Biosciences Holdings, Inc.	$1.73B	$2.36 Million 0.01% of portfolio	68,713	Q4 2024 Reduced 0.89%
AXSM Axsome Therapeutics, Inc.	$4.45B	$2.32 Million 0.01% of portfolio	27,379	Q4 2024 Added 7.97%
VERA Vera Therapeutics, Inc.	$571M	$2.31 Million 0.01% of portfolio	54,599	Q4 2024 Added 52.22%
AGIO Agios Pharmaceuticals, Inc.	$1.53B	$2.25 Million 0.01% of portfolio	68,321	Q4 2024 Added 110.47%
JANX Janux Therapeutics, Inc.	$1.22B	$2.18 Million 0.01% of portfolio	40,733	Q4 2024 Added 25.01%
BBIO Bridge Bio Pharma, Inc.	$5.07B	$2.14 Million 0.01% of portfolio	77,951	Q4 2024 Added 7.06%

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