The Securities and Exchange Commission has not necessarily reviewed the information in this filing and has not determined if it is accurate and complete.
The reader should not assume that the information is accurate and complete.

UNITED STATES SECURITIES AND EXCHANGE COMMISSION
Washington, D.C. 20549
FORM 13F

FORM 13F INFORMATION TABLE
OMB APPROVAL
OMB Number: 3235-0006
Estimated average burden
hours per response: 23.8
COLUMN 1 COLUMN 2 COLUMN 3 COLUMN 4 COLUMN 5 COLUMN 6 COLUMN 7 COLUMN 8
VALUE SHRS OR SH/ PUT/ INVESTMENT OTHER VOTING AUTHORITY
NAME OF ISSUER TITLE OF CLASS CUSIP (x$1000) PRN AMT PRN CALL DISCRETION MANAGER SOLE SHARED NONE
ACADIA PHARMACEUTICALS INC COM 004225108 935 31,046 SH   DFND   31,046 0 0
ACCELERON PHARMA INC COM 00434H108 15,851 373,481 SH   DFND   373,481 0 0
ADAPTIMMUNE THERAPEUTICS PLC SPONDS ADR 00653A107 5,476 853,885 SH   DFND   853,885 0 0
ADVANCED MICRO DEVICES INC NOTE 2.125% 9/0 007903BD8 30,204 20,000,000 PRN   DFND   20,000,000 0 0
AGENUS INC COM NEW 00847G705 9,792 3,201,263 SH   DFND   3,201,263 0 0
ALIBABA GROUP HLDG LTD SPONSORED ADS 01609W102 5,087 29,500 SH   DFND   29,500 0 0
ALLIANCE DATA SYSTEMS CORP COM 018581108 10,431 41,151 SH   DFND   41,151 0 0
ARBUTUS BIOPHARMA CORP COM 03879J100 80,868 16,013,540 SH   DFND   0 16,013,540 0
ARGENX SE SPONSORED ADR 04016X101 11,337 179,560 SH   DFND   179,560 0 0
AVEXIS INC COM 05366U100 5,514 49,823 SH   DFND   49,823 0 0
AXOVANT SCIENCES LTD COM G0750W104 395,250 75,000,000 SH   DFND   0 75,000,000 0
BIOMARIN PHARMACEUTICAL INC COM 09061G101 1,420 15,923 SH   DFND   15,923 0 0
BLUEBIRD BIO INC COM 09609G100 1,236 6,938 SH   DFND   6,938 0 0
CAL MAINE FOODS INC COM NEW 128030202 4,574 102,896 SH   DFND   102,896 0 0
CARMAX INC COM 143130102 9,700 151,253 SH   DFND   151,253 0 0
CTRIP COM INTL LTD AMERICAN DEP SHS 22943F100 4,997 113,300 SH   DFND   113,300 0 0
EQT CORP COM 26884L109 3,889 68,323 SH   DFND   68,323 0 0
EURONAV NV ANTWERPEN SHS B38564108 8,711 941,713 SH   DFND   941,713 0 0
GENER8 MARITIME INC COM Y26889108 4,375 660,940 SH   DFND   660,940 0 0
GOLDMAN SACHS GROUP INC COM 38141G104 14,479 56,832 SH   DFND   56,832 0 0
GULFMARK OFFSHORE INC COM 402629505 615 26,980 SH   DFND   26,980 0 0
HERBALIFE LTD NOTE 2.000% 8/1 42703MAB9 20,755 20,510,000 PRN   DFND   20,510,000 0 0
HIMAX TECHNOLOGIES INC SPONSORED ADR 43289P106 5,038 483,500 SH   DFND   483,500 0 0
HOME DEPOT INC COM 437076102 10,871 57,357 SH   DFND   57,357 0 0
HUNTER MARITIME ACQUISITION *W EXP 99/99/999 Y37828129 15 500,000 SH   DFND   500,000 0 0
HUNTER MARITIME ACQUISITION CL A Y37828111 9,662 1,000,000 SH   DFND   1,000,000 0 0
II VI INC COM 902104108 3,968 84,509 SH   DFND   84,509 0 0
IKANG HEALTHCARE GROUP INC SPONSORED ADR 45174L108 15,033 951,464 SH   DFND   951,464 0 0
INTEL CORP SDCV 3.250% 8/0 458140AF7 6,471 2,895,000 PRN   DFND   2,895,000 0 0
INTERACTIVE BROKERS GROUP IN COM 45841N107 12,510 211,274 SH   DFND   211,274 0 0
INTERCEPT PHARMACEUTICALS IN COM 45845P108 809 13,854 SH   DFND   13,854 0 0
IOVANCE BIOTHERAPEUTICS INC COM 462260100 8,615 1,124,295 SH   DFND   1,124,295 0 0
ISHARES TR IBOXX HI YD ETF 464288513 599 6,870 SH   DFND   6,870 0 0
JEFFERIES GROUP INC NEW DBCV 3.875%11/0 472319AG7 6,543 6,500,000 PRN   DFND   6,500,000 0 0
JPMORGAN CHASE & CO COM 46625H100 8,111 75,849 SH   DFND   75,849 0 0
KEANE GROUP INC COM 48669A108 6,462 339,922 SH   DFND   339,922 0 0
MAKEMYTRIP LIMITED MAURITIUS SHS V5633W109 40,936 1,416,841 SH   DFND   1,416,841 0 0
MICROCHIP TECHNOLOGY INC NOTE 1.625% 2/1 595017AD6 45,408 26,541,000 PRN   DFND   26,541,000 0 0
MICRON TECHNOLOGY INC NOTE 2.125% 2/1 595112AV5 115,271 30,604,000 PRN   DFND   30,604,000 0 0
MYOVANT SCIENCES LTD COM G637AM102 470,604 37,231,342 SH   DFND   0 37,231,342 0
NEW YORK TIMES CO CL A 650111107 14,187 766,889 SH   DFND   766,889 0 0
NEXSTAR MEDIA GROUP INC CL A 65336K103 5,710 73,023 SH   DFND   73,023 0 0
NORDIC AMERICAN TANKERS LIMI COM G65773106 8,547 3,703,929 SH   DFND   3,703,929 0 0
NORDIC AMERICAN TANKERS LIMI COM G65773106 2,507 1,086,200 SH Put DFND   1,086,200 0 0
NORTHSTAR REALTY EUROPE CORP COM 66706L101 11,966 891,000 SH   DFND   891,000 0 0
PATTERSON UTI ENERGY INC COM 703481101 6,698 291,100 SH   DFND   291,100 0 0
PDVWIRELESS INC COM 69290R104 14,020 516,274 SH   DFND   516,274 0 0
QORVO INC COM 74736K101 6,993 105,000 SH   DFND   105,000 0 0
REDFIN CORP COM 75737F108 250 7,970 SH   DFND   7,970 0 0
SAREPTA THERAPEUTICS INC COM 803607100 959 17,231 SH   DFND   17,231 0 0
SINCLAIR BROADCAST GROUP INC CL A 829226109 10,412 275,097 SH   DFND   275,097 0 0
SPDR SERIES TRUST S&P BIOTECH 78464A870 126,881 1,495,000 SH Put DFND   1,495,000 0 0
SPDR SERIES TRUST S&P BIOTECH 78464A870 28,649 337,567 SH   DFND   337,567 0 0
TESARO INC COM 881569107 962 11,605 SH   DFND   11,605 0 0
TIME WARNER INC COM NEW 887317303 20,877 228,244 SH   DFND   228,244 0 0
TRACON PHARMACEUTICALS INC COM 89237H100 397 124,966 SH   DFND   124,966 0 0
TRIBUNE MEDIA CO CL A 896047503 3,208 75,544 SH   DFND   75,544 0 0
VECTOR GROUP LTD COM 92240M108 256 11,428 SH   DFND   11,428 0 0
VECTOR GROUP LTD FRNT 1/1 92240MAY4 742 467,000 PRN   DFND   467,000 0 0
VERISIGN INC SDCV 3.250% 8/1 92343EAD4 89,442 26,624,000 PRN   DFND   26,624,000 0 0
WELLS FARGO CO NEW COM 949746101 5,964 98,300 SH   DFND   98,300 0 0