The Securities and Exchange Commission has not necessarily reviewed the information in this filing and has not determined if it is accurate and complete.
The reader should not assume that the information is accurate and complete.

UNITED STATES SECURITIES AND EXCHANGE COMMISSION
Washington, D.C. 20549
FORM 13F

FORM 13F INFORMATION TABLE
OMB APPROVAL
OMB Number: 3235-0006
Estimated average burden
hours per response: 23.8
COLUMN 1 COLUMN 2 COLUMN 3 COLUMN 4 COLUMN 5 COLUMN 6 COLUMN 7 COLUMN 8
VALUE SHRS OR SH/ PUT/ INVESTMENT OTHER VOTING AUTHORITY
NAME OF ISSUER TITLE OF CLASS CUSIP (x$1000) PRN AMT PRN CALL DISCRETION MANAGER SOLE SHARED NONE
89BIO INC COM 282559103 3,814 658,784 SH   DFND 1,2 658,784 0 0
ABBVIE INC COM 00287Y109 21,780 162,285 SH   DFND 1,2 162,285 0 0
ADOBE SYSTEMS INCORPORATED COM 00724F101 8,022 29,150 SH   DFND   29,150 0 0
ALBIREO PHARMA INC COM 01345P106 6,950 359,000 SH   DFND 1,2 359,000 0 0
ALPINE IMMUNE SCIENCES INC COM 02083G100 1,440 200,000 SH   DFND 1,2 200,000 0 0
ALTIMMUNE INC COM NEW 02155H200 7,666 600,298 SH   DFND 1,2 600,298 0 0
ALTIMMUNE INC PUT 02155H950 1,277 100,000 SH Put DFND 1,2 100,000 0 0
ARBE ROBOTICS LTD ORDINARY SHARES M1R95N100 259 43,165 SH   DFND   43,165 0 0
ARCELLX INC COMMON STOCK 03940C100 6,271 334,080 SH   DFND 1,2 334,080 0 0
ASTRAZENECA PLC SPONSORED ADR 046353108 49,195 897,060 SH   DFND 1,2 897,060 0 0
BELLUS HEALTH INC NEW COM NEW 07987C204 4,909 464,860 SH   DFND 1,2 464,860 0 0
BIOGEN INC COM 09062X103 14,819 55,500 SH   DFND 1,2 55,500 0 0
CHINOOK THERAPEUTICS INC COM 16961L106 10,505 534,358 SH   DFND 1,2 534,358 0 0
CINCOR PHARMA INC COM 17240Y109 3,904 118,950 SH   DFND 1,2 118,950 0 0
CONCERT PHARMACEUTICALS INC COM 206022105 6,384 952,783 SH   DFND 1,2 952,783 0 0
CRINETICS PHARMACEUTICALS IN COM 22663K107 12,305 626,552 SH   DFND 1,2 626,552 0 0
CYCLACEL PHARMACEUTICALS INC COM 23254L603 365 250,000 SH   DFND 1,2 250,000 0 0
DICE THERAPEUTICS INC COM 23345J104 3,101 152,913 SH   DFND 1,2 152,913 0 0
DICE THERAPEUTICS INC PUT 23345J954 3,042 150,000 SH Put DFND 1,2 150,000 0 0
EDGEWISE THERAPEUTICS INC COM 28036F105 590 60,000 SH   DFND 1,2 60,000 0 0
FIVERR INTL LTD NOTE 11/0 33835LAA3 3,900 4,951,000 SH   DFND   4,951,000 0 0
GENERAC HLDGS INC CALL 368736904 6,342 35,600 SH Call DFND   0 0 35,600
GILEAD SCIENCES INC COM 375558103 6,483 105,090 SH   DFND 1,2 105,090 0 0
GLOBAL E ONLINE LTD SHS M5216V106 8,335 311,460 SH   DFND   311,460 0 0
ICL GROUP LTD SHS M53213100 912 111,482 SH   DFND   111,482 0 0
IMMATICS N.V *W EXP 07/01/202 N44445117 271 100,000 SH   DFND 1,2 100,000 0 0
IMMATICS N.V SHS N44445109 7,954 795,406 SH   DFND 1,2 795,406 0 0
INFINITY PHARMACEUTICALS INC COM 45665G303 1,756 1,476,000 SH   DFND 1,2 1,476,000 0 0
INOZYME PHARMA INC COM 45790W108 3,149 1,175,058 SH   DFND 1,2 1,175,058 0 0
INVESCO QQQ TR PUT 46090E953 86,993 325,500 SH Put DFND   325,500 0 0
IVERIC BIO INC COM 46583P102 10,438 581,829 SH   DFND 1,2 581,829 0 0
JOHNSON & JOHNSON COM 478160104 35,310 216,151 SH   DFND 1,2 216,151 0 0
KEROS THERAPEUTICS INC COM 492327101 7,781 206,819 SH   DFND 1,2 206,819 0 0
KEZAR LIFE SCIENCES INC COM 49372L100 10,726 1,245,806 SH   DFND 1,2 1,245,806 0 0
KORNIT DIGITAL LTD SHS M6372Q113 8,593 322,926 SH   DFND   322,926 0 0
KURA ONCOLOGY INC COM 50127T109 10,791 789,952 SH   DFND 1,2 789,952 0 0
LILLY ELI & CO COM 532457108 46,417 143,550 SH   DFND 1,2 143,550 0 0
MAGIC SOFTWARE ENTERPRISES L ORD 559166103 1,265 81,293 SH   DFND   81,293 0 0
MEDIWOUND LTD ORD SHS M68830104 477 342,858 SH   DFND 1,2 342,858 0 0
MEDIWOUND LTD ORD SHS M68830104 481 345,858 SH   DFND   345,858 0 0
MERCK & CO INC COM 58933Y105 31,606 367,000 SH   DFND 1,2 367,000 0 0
MERUS N V COM N5749R100 6,276 313,326 SH   DFND 1,2 313,326 0 0
NICE LTD SPONSORED ADR 653656108 592 3,145 SH   DFND   3,145 0 0
NICE SYS INC NOTE 1.250% 1/1 65366HAB9 571 250,000 SH   DFND   250,000 0 0
NOVO-NORDISK A S ADR 670100205 29,534 296,440 SH   DFND 1,2 296,440 0 0
NVIDIA CORPORATION COM 67066G104 4,856 40,000 SH   DFND   40,000 0 0
NVIDIA CORPORATION CALL 67066G904 20,952 172,600 SH Call DFND   0 0 0
ONCORUS INC COM 68236R103 459 540,258 SH   DFND 1,2 540,258 0 0
OTONOMO TECHNOLOGIES LTD ORDINARY SHARES M7571L103 111 391,863 SH   DFND   391,863 0 0
PALO ALTO NETWORKS INC COM 697435105 10,319 63,000 SH   DFND   63,000 0 0
PERION NETWORK LTD SHS NEW M78673114 7,816 405,184 SH   DFND   405,184 0 0
PMV PHARMACEUTICALS INC COM 69353Y103 2,235 187,800 SH   DFND 1,2 187,800 0 0
POINT BIOPHARMA GLOBAL INC COM 730541109 8,138 1,052,842 SH   DFND 1,2 1,052,842 0 0
POSEIDA THERAPEUTICS INC COM 73730P108 1,059 300,000 SH   DFND 1,2 300,000 0 0
RELMADA THERAPEUTICS INC COM 75955J402 7,153 193,230 SH   DFND 1,2 193,230 0 0
RELMADA THERAPEUTICS INC PUT 75955J952 3,443 93,000 SH Put DFND 1,2 93,000 0 0
REZOLUTE INC COM NEW 76200L309 3,167 1,155,897 SH   DFND 1,2 1,155,897 0 0
RIGEL PHARMACEUTICALS INC COM NEW 766559603 2,552 2,162,586 SH   DFND 1,2 2,162,586 0 0
SANOFI SPONSORED ADR 80105N105 46,176 1,214,515 SH   DFND 1,2 1,214,515 0 0
SENTINELONE INC CL A 81730H109 7,157 280,000 SH   DFND   280,000 0 0
SENTINELONE INC CALL 81730H909 4,212 164,800 SH Call DFND   0 0 367,500
SOLAREDGE TECHNOLOGIES INC COM 83417M104 6,811 29,426 SH   DFND   29,426 0 0
SPRINGWORKS THERAPEUTICS INC COM 85205L107 8,605 301,625 SH   DFND 1,2 301,625 0 0
STOKE THERAPEUTICS INC COM 86150R107 2,018 157,200 SH   DFND 1,2 157,200 0 0
SUNRUN INC COM 86771W105 1,793 65,000 SH   DFND   65,000 0 0
SYNDAX PHARMACEUTICALS INC COM 87164F105 19,769 822,696 SH   DFND 1,2 822,696 0 0
TEVA PHARMACEUTICAL INDS LTD SPONSORED ADS 881624209 6,265 776,346 SH   DFND   776,346 0 0
TEVA PHARMACEUTICAL INDS LTD CALL 881624909 17,835 2,210,000 SH Call DFND   0 0 172,600
ULTRAGENYX PHARMACEUTICAL IN COM 90400D108 7,193 173,696 SH   DFND 1,2 173,696 0 0
UNITY SOFTWARE INC COM 91332U101 366 11,500 SH   DFND   11,500 0 0
UNITY SOFTWARE INC CALL 91332U901 11,709 367,500 SH Call DFND   0 0 367,500
VERONA PHARMA PLC SPONSORED ADS 925050106 1,226 120,000 SH   DFND 1,2 120,000 0 0
WEREWOLF THERAPEUTICS INC COM 95075A107 2,827 626,810 SH   DFND 1,2 626,810 0 0
WIX COM LTD SHS M98068105 10,092 129,000 SH   DFND   129,000 0 0
WIX COM LTD NOTE 8/1 92940WAD1 591 700,000 SH   DFND   700,000 0 0