The Securities and Exchange Commission has not necessarily reviewed the information in this filing and has not determined if it is accurate and complete.
The reader should not assume that the information is accurate and complete.

UNITED STATES SECURITIES AND EXCHANGE COMMISSION
Washington, D.C. 20549
FORM 13F

FORM 13F INFORMATION TABLE
OMB APPROVAL
OMB Number: 3235-0006
Estimated average burden
hours per response: 23.8
COLUMN 1 COLUMN 2 COLUMN 3 COLUMN 4 COLUMN 5 COLUMN 6 COLUMN 7 COLUMN 8
VALUE SHRS OR SH/ PUT/ INVESTMENT OTHER VOTING AUTHORITY
NAME OF ISSUER TITLE OF CLASS CUSIP (x$1000) PRN AMT PRN CALL DISCRETION MANAGER SOLE SHARED NONE
ACASTI PHARMA INC CL A NEW 00430K402 63 61,509 SH   DFND 12,8 61,509 0 0
ADVAXIS INC COM NEW 007624307 1,244 210,570 SH   DFND 12,8 210,570 0 0
AEGLEA BIOTHERAPEUTICS INC COM 00773J103 2,186 271,542 SH   DFND 12,8 271,542 0 0
AILERON THERAPEUTICS INC COM 00887A105 110 56,611 SH   DFND 12,8 56,611 0 0
AMERI HLDGS INC *W EXP 11/08/202 02362F112 8 99,500 SH   DFND 12,8 99,500 0 0
ANI PHARMACEUTICALS INC NOTE 3.000%12/0 00182CAA1 9,887 9,000,000 PRN   DFND 12,8 0 0 0
APPLIED DNA SCIENCES INC *W EXP 11/21/201 03815U110 1 31,407 SH   DFND 12,8 31,407 0 0
APTEVO THERAPEUTICS INC COM 03835L108 703 780,720 SH   DFND 12,8 780,720 0 0
AURYN RES INC COM 05208W108 679 468,610 SH   DFND 12,8 468,610 0 0
AXOVANT SCIENCES LTD COM G0750W104 8,164 6,138,402 SH   DFND 12,8 6,138,402 0 0
BEASLEY BROADCAST GROUP INC CL A 074014101 894 224,733 SH   DFND 12,8 224,733 0 0
BENITEC BIOPHARMA LTD *W EXP 08/14/202 082053117 6 50,000 SH   DFND 12,8 50,000 0 0
BIONDVAX PHARMACEUTICALS LTD *W EXP 05/15/202 09073Q113 25 72,800 SH   DFND 12,8 72,800 0 0
BLUEPRINT MEDICINES CORP COM 09627Y109 16,010 200,000 SH   DFND 12,8 200,000 0 0
CELLECT BIOTECHNOLOGY LTD *W EXP 08/03/202 15116C110 1 12,498 SH   DFND 12,8 12,498 0 0
CHECK CAP LTD *W EXP 05/03/202 M2361E161 52 136,364 SH   DFND 12,8 136,364 0 0
CHIASMA INC COM 16706W102 321 61,805 SH   DFND 12,8 61,805 0 0
CO DIAGNOSTICS INC COM 189763105 751 708,565 SH   DFND 12,8 708,565 0 0
CORMEDIX INC COM 21900C308 269 28,500 SH Put DFND 12,8 0 0 0
CREATIVE REALITIES INC *W EXP 11/09/202 22530J119 6 15,000 SH   DFND 12,8 15,000 0 0
CYTORI THERAPEUTICS INC *W EXP 05/28/202 23283K139 1 259,200 SH   DFND 12,8 259,200 0 0
ELECTRAMECCANICA VEHS CORP COM NEW 284849205 693 194,653 SH   DFND 12,8 194,653 0 0
EROS INTL PLC SHS NEW G3788M114 4,560 498,909 SH   DFND 12,8 498,909 0 0
EYEPOINT PHARMACEUTICALS INC COM 30233G100 2,658 1,484,714 SH   DFND 12,8 1,484,714 0 0
FLEXSHOPPER INC *W EXP 09/28/202 33939J113 14 50,000 SH   DFND 12,8 50,000 0 0
FUELCELL ENERGY INC COM NEW 35952H502 8 33,254 SH   DFND 12,8 33,254 0 0
GENFIT S A ADS 372279109 9,600 400,000 SH   DFND 12,8 400,000 0 0
HEAT BIOLOGICS INC COM NEW 42237K300 440 346,599 SH   DFND 12,8 346,599 0 0
IMMUCELL CORP COM PAR 452525306 64 10,000 SH   DFND 12,8 10,000 0 0
IMMURON LTD *W EXP 05/12/202 Q4867H223 15 10,941 SH   DFND 12,8 10,941 0 0
IMV INC COM 44974L103 119 29,661 SH   DFND 12,8 29,661 0 0
INSPIREMD INC *W EXP 03/14/202 45779A135 0 48,000 SH   DFND 12,8 48,000 0 0
INVIVO THERAPEUTICS HLDGS CO COM PAR 46186M407 116 74,566 SH   DFND 12,8 74,566 0 0
KOPIN CORP COM 500600101 1,856 1,384,944 SH   DFND 12,8 1,384,944 0 0
LIQUIDIA TECHNOLOGIES INC COM 53635D202 330 28,987 SH   DFND 12,8 28,987 0 0
MANNKIND CORP COM NEW 56400P706 908 461,140 SH   DFND 12,8 461,140 0 0
MATINAS BIOPHARMA HLDGS INC COM 576810105 991 909,625 SH   DFND 12,8 909,625 0 0
MEDIGUS LTD *W EXP 07/23/202 58471G128 29 64,286 SH   DFND 12,8 64,286 0 0
MERSANA THERAPEUTICS INC COM 59045L106 442 83,969 SH   DFND 12,8 83,969 0 0
MOLECULIN BIOTECH INC COM 60855D101 294 362,729 SH   DFND 12,8 362,729 0 0
MYND ANALYTICS INC *W EXP 06/29/202 62857N111 1 13,700 SH   DFND 12,8 13,700 0 0
NANOSTRING TECHNOLOGIES INC COM 63009R109 18,523 774,068 SH   DFND 12,8 774,068 0 0
NEOVASC INC COM NEW 64065J205 21 50,794 SH   DFND 12,8 50,794 0 0
NOVAN INC COM 66988N106 68 71,515 SH   DFND 12,8 71,515 0 0
ONCONOVA THERAPEUTICS INC *W EXP 07/11/202 68232V116 7 132,227 SH   DFND 12,8 132,227 0 0
ORAGENICS INC COM PAR 684023302 1,984 3,391,165 SH   DFND 12,8 3,391,165 0 0
PHIO PHARMACEUTICALS CORP COM 71880W204 272 604,939 SH   DFND 12,8 604,939 0 0
SEANERGY MARITIME HLDGS CORP *W EXP 11/10/202 Y73760145 27 1,180,400 SH   DFND 12,8 1,180,400 0 0
SENSEONICS HLDGS INC NOTE 5.250% 2/0 81727UAA3 1,590 1,500,000 PRN   DFND 12,8 0 0 0
SHARPSPRING INC COM 820054104 242 15,131 SH   DFND 12,8 15,131 0 0
SIGMA LABS INC *W EXP 02/15/202 826598112 129 199,836 SH   DFND 12,8 199,836 0 0
SOLIGENIX INC *W EXP 11/14/202 834223117 2 16,599 SH   DFND 12,8 16,599 0 0
THERAPIX BIOSCIENCES LTD SPONSORED ADS NE 88339A203 98 31,397 SH   DFND 12,8 31,397 0 0
TIMKENSTEEL CORP NOTE 6.000% 6/0 887399AA1 12,194 10,455,000 PRN   DFND 12,8 0 0 0
TITAN MED INC COM NEW 88830X819 2,135 762,371 SH   DFND 12,8 762,371 0 0
VALERITAS HLDGS INC COM NEW 91914N202 35 106,845 SH   DFND 12,8 106,845 0 0
VASCULAR BIOGENICS LTD COM M96883109 1,663 1,094,044 SH   DFND 12,8 1,094,044 0 0
VTV THERAPEUTICS INC CL A 918385105 2,102 1,229,153 SH   DFND 12,8 1,229,153 0 0