The Securities and Exchange Commission has not necessarily reviewed the information in this filing and has not determined if it is accurate and complete.
The reader should not assume that the information is accurate and complete.

UNITED STATES SECURITIES AND EXCHANGE COMMISSION
Washington, D.C. 20549
FORM 13F

FORM 13F INFORMATION TABLE
OMB APPROVAL
OMB Number: 3235-0006
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COLUMN 1 COLUMN 2 COLUMN 3 COLUMN 4 COLUMN 5 COLUMN 6 COLUMN 7 COLUMN 8
VALUE SHRS OR SH/ PUT/ INVESTMENT OTHER VOTING AUTHORITY
NAME OF ISSUER TITLE OF CLASS CUSIP FIGI (to the nearest dollar) PRN AMT PRN CALL DISCRETION MANAGER SOLE SHARED NONE
ACRIVON THERAPEUTICS INC COMMON STOCK 004890109   38,169,718 3,007,858 SH   SOLE   3,007,858 0 0
ADC THERAPEUTICS SA SHS H0036K147   2,916,820 1,495,805 SH   SOLE   1,495,805 0 0
ADMA BIOLOGICS INC COM 000899104   39,389,844 11,900,255 SH   SOLE   11,900,255 0 0
AKERO THERAPEUTICS INC COM 00973Y108   20,030,067 523,525 SH   SOLE   523,525 0 0
ALDEYRA THERAPEUTICS INC COM 01438T106   112,706,344 11,350,085 SH   SOLE   11,350,085 0 0
AMICUS THERAPEUTICS INC COM 03152W109   306,781,750 27,662,917 SH   SOLE   27,662,917 0 0
AMYLYX PHARMACEUTICALS INC COM 03237H101   177,056,455 6,034,644 SH   SOLE   6,034,644 0 0
APELLIS PHARMACEUTICALS INC COM 03753U106   36,630,490 555,344 SH   SOLE   555,344 0 0
ARCELLX INC COMMON STOCK 03940C100   118,363,979 3,841,739 SH   SOLE   3,841,739 0 0
ARTIVION INC COM 228903100   14,224,766 1,085,860 SH   SOLE   1,085,860 0 0
ASTRIA THERAPEUTICS INC COM 04635X102   29,119,844 2,189,462 SH   SOLE   2,189,462 0 0
ATHENEX INC COM NEW 04685N202   1,032,909 776,623 SH   SOLE   776,623 0 0
ATHIRA PHARMA INC COM 04746L104   11,993,195 4,797,278 SH   SOLE   4,797,278 0 0
AVADEL PHARMACEUTICALS PLC SPONSORED ADR 05337M104   5,404,400 590,000 SH   SOLE   590,000 0 0
AXOGEN INC COM 05463X106   13,322,525 1,409,791 SH   SOLE   1,409,791 0 0
BELLEROPHON THERAPEUTICS INC COM NEW 078771300   7,337,700 930,000 SH   SOLE   930,000 0 0
BELLUS HEALTH INC NEW COM NEW 07987C204   35,658,274 4,952,538 SH   SOLE   4,952,538 0 0
BIOMARIN PHARMACEUTICAL INC COM 09061G101   65,448,354 673,060 SH   SOLE   673,060 0 0
BIOMEA FUSION INC COM 09077A106   10,078,250 325,000 SH   SOLE   325,000 0 0
BRIDGEBIO PHARMA INC COM 10806X102   31,618,607 1,907,033 SH   SOLE   1,907,033 0 0
CABALETTA BIO INC COM 12674W109   5,993,906 724,777 SH   SOLE   724,777 0 0
CAREMAX INC COM CL A 14171W103   9,548,027 3,576,040 SH   SOLE   3,576,040 0 0
CAREMAX INC *W EXP 06/08/202 14171W111   28,908 60,000 SH   SOLE   60,000 0 0
CEREVEL THERAPEUTICS HLDNG I COM 15678U128   158,851,021 6,511,727 SH   SOLE   6,511,727 0 0
CLOVER HEALTH INVESTMENTS CO COM CL A 18914F103   1,267,650 1,500,000 SH   SOLE   1,500,000 0 0
COGENT BIOSCIENCES INC COM 19240Q201   24,626,276 2,282,324 SH   SOLE   2,282,324 0 0
CRINETICS PHARMACEUTICALS IN COM 22663K107   57,091,485 3,554,887 SH   SOLE   3,554,887 0 0
CYMABAY THERAPEUTICS INC COM 23257D103   34,036,384 3,903,255 SH   SOLE   3,903,255 0 0
CYTEK BIOSCIENCES INC COM 23285D109   11,850,817 1,289,534 SH   SOLE   1,289,534 0 0
DARIOHEALTH CORP COM NEW 23725P209   1,293,140 313,869 SH   SOLE   313,869 0 0
ENVVENO MEDICAL CORPORATION COM 29415J106   3,657,958 781,615 SH   SOLE   781,615 0 0
EQRX INC *W EXP 12/17/202 26886C115   43,125 250,000 SH   SOLE   250,000 0 0
ESTABLISHMENT LABS HLDGS INC COM G31249108   31,692,633 467,857 SH   SOLE   467,857 0 0
FUSION PHARMACEUTICALS INC COM 36118A100   10,404,959 2,759,936 SH   SOLE   2,759,936 0 0
HARMONY BIOSCIENCES HLDGS IN COM 413197104   3,265,000 100,000 SH   SOLE   100,000 0 0
HILLEVAX INC COM 43157M102   6,711,577 406,024 SH   SOLE   406,024 0 0
IMMATICS N.V SHS N44445109   24,091,350 3,491,500 SH   SOLE   3,491,500 0 0
IMMUNOVANT INC COM 45258J102   20,036,718 1,291,858 SH   SOLE   1,291,858 0 0
INHIBRX INC COM 45720L107   68,222,277 3,615,383 SH   SOLE   3,615,383 0 0
INTUITIVE SURGICAL INC COM NEW 46120E602   12,773,500 50,000 SH   SOLE   50,000 0 0
IOVANCE BIOTHERAPEUTICS INC COM 462260100   93,725,780 15,339,735 SH   SOLE   15,339,735 0 0
IVERIC BIO INC COM 46583P102   12,165,000 500,000 SH   SOLE   500,000 0 0
KRONOS BIO INC COM 50107A104   2,558,131 1,752,745 SH   SOLE   1,752,745 0 0
LANDOS BIOPHARMA INC COM 515069102   4,431,234 14,869,915 SH   SOLE   14,869,915 0 0
LARIMAR THERAPEUTICS INC COM 517125100   10,331,612 2,280,709 SH   SOLE   2,280,709 0 0
LEAP THERAPEUTICS INC COM 52187K101   2,287,009 6,726,496 SH   SOLE   6,726,496 0 0
LIANBIO SPONSORED ADS 53000N108   112,814,563 57,558,451 SH   SOLE   57,558,451 0 0
LYRA THERAPEUTICS INC COM 55234L105   18,384,927 9,146,730 SH   SOLE   9,146,730 0 0
MADRIGAL PHARMACEUTICALS INC COM 558868105   157,605,150 650,562 SH   SOLE   650,562 0 0
MEIRAGTX HLDGS PLC COM G59665102   35,980,599 6,963,277 SH   SOLE   6,963,277 0 0
MIRATI THERAPEUTICS INC COM 60468T105   58,526,302 1,574,134 SH   SOLE   1,574,134 0 0
MIRUM PHARMACEUTICALS INC COM 604749101   14,449,615 601,566 SH   SOLE   601,566 0 0
MORPHIC HLDG INC COM 61775R105   9,663,581 256,737 SH   SOLE   256,737 0 0
MOTUS GI HLDGS INC COM NEW 62014P405   87,641 90,027 SH   SOLE   90,027 0 0
NANOBIOTIX SPONSORED ADS 63009J107   3,735,795 1,059,800 SH   SOLE   1,059,800 0 0
NATERA INC COM 632307104   39,264,521 707,214 SH   SOLE   707,214 0 0
NAUTILUS BIOTECHNOLOGY INC COM 63909J108   25,237,888 9,111,151 SH   SOLE   9,111,151 0 0
NEUROCRINE BIOSCIENCES INC COM 64125C109   10,127,061 100,050 SH   SOLE   100,050 0 0
NUVALENT INC COM 670703107   60,008,252 2,300,048 SH   SOLE   2,300,048 0 0
ORCHESTRA BIOMED HLDGS INC COM 68572M106   44,584,883 2,278,226 SH   SOLE   2,278,226 0 0
OUTSET MED INC COM 690145107   20,045,457 1,089,427 SH   SOLE   1,089,427 0 0
PEAR THERAPEUTICS INC COM 704723105   229,639 900,548 SH   SOLE   900,548 0 0
PHENOMEX INC COM 084310101   2,907,473 2,506,442 SH   SOLE   2,506,442 0 0
PROMETHEUS BIOSCIENCES INC COM 74349U108   136,585,520 1,272,694 SH   SOLE   1,272,694 0 0
PROTAGONIST THERAPEUTICS INC COM 74366E102   22,198,496 965,152 SH   SOLE   965,152 0 0
PROTARA THERAPEUTICS INC COM STK 74365U107   907,860 290,051 SH   SOLE   290,051 0 0
PROTHENA CORP PLC SHS G72800108   11,518,702 237,646 SH   SOLE   237,646 0 0
QUANTERIX CORP COM 74766Q101   1,465,100 130,000 SH   SOLE   130,000 0 0
RAIN ONCOLOGY INC COM 75082Q105   14,405,399 1,648,215 SH   SOLE   1,648,215 0 0
RAPT THERAPEUTICS INC COM 75382E109   42,051,007 2,291,608 SH   SOLE   2,291,608 0 0
REATA PHARMACEUTICALS INC CL A 75615P103   197,230,574 2,169,276 SH   SOLE   2,169,276 0 0
RELAY THERAPEUTICS INC COM 75943R102   32,002,807 1,943,097 SH   SOLE   1,943,097 0 0
ROCKET PHARMACEUTICALS INC COM 77313F106   14,864,249 867,732 SH   SOLE   867,732 0 0
ROIVANT SCIENCES LTD SHS G76279101   19,867,964 2,692,136 SH   SOLE   2,692,136 0 0
SANOFI SPONSORED ADR 80105N105   41,800,056 768,101 SH   SOLE   768,101 0 0
SAREPTA THERAPEUTICS INC COM 803607100   35,954,058 260,858 SH   SOLE   260,858 0 0
SINGULAR GENOMICS SYSTEMS IN COM 82933R100   3,971,553 3,282,275 SH   SOLE   3,282,275 0 0
SOLID BIOSCIENCES INC COM NEW 83422E204   16,570,722 3,495,933 SH   SOLE   3,495,933 0 0
SOMALOGIC INC CLASS A COM 83444K105   3,825,000 1,500,000 SH   SOLE   1,500,000 0 0
SPDR SER TR S&P BIOTECH 78464A870   7,621,000 100,000 SH Put SOLE   100,000 0 0
SPRINGWORKS THERAPEUTICS INC COM 85205L107   53,522,520 2,079,352 SH   SOLE   2,079,352 0 0
SURROZEN INC *W EXP 08/01/203 86889P117   16,667 166,666 SH   SOLE   166,666 0 0
TACTILE SYS TECHNOLOGY INC COM 87357P100   10,506,780 639,877 SH   SOLE   639,877 0 0
TARSUS PHARMACEUTICALS INC COM 87650L103   16,295,949 1,296,416 SH   SOLE   1,296,416 0 0
TERNS PHARMACEUTICALS INC COM 880881107   15,984,000 1,350,000 SH   SOLE   1,350,000 0 0
TRAVERE THERAPEUTICS INC COM 89422G107   2,040,923 90,748 SH   SOLE   90,748 0 0
TREACE MED CONCEPTS INC COM 89455T109   61,520,278 2,442,250 SH   SOLE   2,442,250 0 0
TYRA BIOSCIENCES INC COM 90240B106   7,945,056 494,403 SH   SOLE   494,403 0 0
VAXCYTE INC COM 92243G108   43,851,600 1,170,000 SH   SOLE   1,170,000 0 0
VBI VACCINES INC CDA COM NEW 91822J103   471,015,018 52,335,002 SH   SOLE   52,335,002 0 0
VERONA PHARMA PLC SPONSORED ADS 925050106   54,894,503 2,733,790 SH   SOLE   2,733,790 0 0
VERRICA PHARMACEUTICALS INC COM 92511W108   32,753,389 5,038,983 SH   SOLE   5,038,983 0 0
VERU INC COM 92536C103   4,985,926 4,298,212 SH   SOLE   4,298,212 0 0
VIKING THERAPEUTICS INC COM 92686J106   14,514,588 871,747 SH   SOLE   871,747 0 0
VIR BIOTECHNOLOGY INC COM 92764N102   3,308,854 142,194 SH   SOLE   142,194 0 0
VIRIDIAN THERAPEUTICS INC COM 92790C104   44,173,660 1,736,386 SH   SOLE   1,736,386 0 0
X4 PHARMACEUTICALS INC COM 98420X103   3,954,545 4,545,454 SH   SOLE   4,545,454 0 0
XENON PHARMACEUTICALS INC COM 98420N105   65,573,507 1,832,174 SH   SOLE   1,832,174 0 0
ZYMEWORKS INC COM 98985Y108   30,541,621 3,378,498 SH   SOLE   3,378,498 0 0