The Securities and Exchange Commission has not necessarily reviewed the information in this filing and has not determined if it is accurate and complete. | |||||||||||||||||
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UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 13F FORM 13F INFORMATION TABLE |
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| COLUMN 1 | COLUMN 2 | COLUMN 3 | COLUMN 4 | COLUMN 5 | COLUMN 6 | COLUMN 7 | COLUMN 8 | |||||
| VALUE | SHRS OR | SH/ | PUT/ | INVESTMENT | OTHER | VOTING AUTHORITY | ||||||
| NAME OF ISSUER | TITLE OF CLASS | CUSIP | FIGI | (to the nearest dollar) | PRN AMT | PRN | CALL | DISCRETION | MANAGER | SOLE | SHARED | NONE |
| 4D MOLECULAR THERAPEUTICS IN | COM | 35104E100 | 79,806,360 | 7,382,642 | SH | DFND | 1 | 0 | 7,382,642 | 0 | ||
| 89BIO INC | COM | 282559103 | 50,406,069 | 6,811,631 | SH | DFND | 1 | 0 | 6,811,631 | 0 | ||
| AC IMMUNE SA | SHS | H00263105 | 73,794,808 | 19,522,436 | SH | DFND | 1 | 0 | 19,522,436 | 0 | ||
| AGIOS PHARMACEUTICALS INC | COM | 00847X104 | 52,876,454 | 1,190,107 | SH | DFND | 1 | 0 | 1,190,107 | 0 | ||
| ALLAKOS INC | COM | 01671P100 | 10,812,039 | 16,552,417 | SH | DFND | 1 | 0 | 16,552,417 | 0 | ||
| ANNEXON INC | COM | 03589W102 | 41,440,000 | 7,000,000 | SH | DFND | 1 | 0 | 7,000,000 | 0 | ||
| AVALO THERAPEUTICS INC | COM NEW | 05338F306 | 9,147,820 | 967,000 | SH | DFND | 1 | 0 | 967,000 | 0 | ||
| AXSOME THERAPEUTICS INC | COM | 05464T104 | 94,004,020 | 1,046,000 | SH | DFND | 1 | 0 | 1,046,000 | 0 | ||
| CELCUITY INC | COM | 15102K100 | 51,678,060 | 3,466,000 | SH | DFND | 1 | 0 | 3,466,000 | 0 | ||
| CG ONCOLOGY INC | COM | 156944100 | 37,526,107 | 994,596 | SH | DFND | 1 | 0 | 994,596 | 0 | ||
| CIDARA THERAPEUTICS INC | COM NEW | 171757206 | 7,557,949 | 703,065 | SH | DFND | 1 | 0 | 703,065 | 0 | ||
| CULLINAN THERAPEUTICS INC | COM | 230031106 | 96,266,433 | 5,750,683 | SH | DFND | 1 | 0 | 5,750,683 | 0 | ||
| CYTOMX THERAPEUTICS INC | COM | 23284F105 | 6,169,584 | 5,228,461 | SH | DFND | 1 | 0 | 5,228,461 | 0 | ||
| ELEDON PHARMACEUTICALS INC | COM | 28617K101 | 15,670,272 | 6,293,282 | SH | DFND | 1 | 0 | 6,293,282 | 0 | ||
| ELEVATION ONCOLOGY INC | COM | 28623U101 | 1,779,805 | 2,966,836 | SH | DFND | 1 | 0 | 2,966,836 | 0 | ||
| ENGENE HOLDINGS INC | COM | 29286M105 | 14,856,844 | 2,251,037 | SH | DFND | 1 | 0 | 2,251,037 | 0 | ||
| ENGENE HOLDINGS INC | *W EXP 10/31/202 | 29286M113 | 803,686 | 945,402 | SH | DFND | 1 | 0 | 945,402 | 0 | ||
| ESSA PHARMA INC | COM NEW | 29668H708 | 53,016,692 | 8,748,629 | SH | DFND | 1 | 0 | 8,748,629 | 0 | ||
| FOGHORN THERAPEUTICS INC | COM | 344174107 | 49,361,620 | 5,302,000 | SH | DFND | 1 | 0 | 5,302,000 | 0 | ||
| FORTE BIOSCIENCES INC | COM NEW | 34962G208 | 667,979 | 119,282 | SH | DFND | 1 | 0 | 119,282 | 0 | ||
| GALAPAGOS NV | SPON ADR | 36315X101 | 45,183,659 | 1,569,422 | SH | DFND | 1 | 0 | 1,569,422 | 0 | ||
| GH RESEARCH PLC | ORDINARY SHARES | G3855L106 | 69,577,057 | 10,400,158 | SH | DFND | 1 | 0 | 10,400,158 | 0 | ||
| GLYCOMIMETICS INC | COM | 38000Q102 | 1,612,980 | 9,544,262 | SH | DFND | 1 | 0 | 9,544,262 | 0 | ||
| IDEAYA BIOSCIENCES INC | COM | 45166A102 | 44,668,578 | 1,409,993 | SH | DFND | 1 | 0 | 1,409,993 | 0 | ||
| IKENA ONCOLOGY INC | COM | 45175G108 | 8,250,654 | 4,769,164 | SH | DFND | 1 | 0 | 4,769,164 | 0 | ||
| IMMUNIC INC | COM | 4525EP101 | 14,689,904 | 8,902,972 | SH | DFND | 1 | 0 | 8,902,972 | 0 | ||
| INVENTIVA SA | ADS | 46124U107 | 1,269,174 | 686,040 | SH | DFND | 1 | 0 | 686,040 | 0 | ||
| IONIS PHARMACEUTICALS INC | COM | 462222100 | 58,162,273 | 1,451,879 | SH | DFND | 1 | 0 | 1,451,879 | 0 | ||
| KURA ONCOLOGY INC | COM | 50127T109 | 65,884,210 | 3,371,761 | SH | DFND | 1 | 0 | 3,371,761 | 0 | ||
| KYMERA THERAPEUTICS INC | COM | 501575104 | 244,308,041 | 5,161,801 | SH | DFND | 1 | 0 | 5,161,801 | 0 | ||
| MIRUM PHARMACEUTICALS INC | COM | 604749101 | 119,960,373 | 3,075,907 | SH | DFND | 1 | 0 | 3,075,907 | 0 | ||
| MOLECULAR PARTNERS AG | ADS | 60853G106 | 2,136,325 | 443,221 | SH | DFND | 1 | 0 | 443,221 | 0 | ||
| MOLECULAR TEMPLATES INC | COM NEW | 608550208 | 733,744 | 522,238 | SH | DFND | 1 | 0 | 522,238 | 0 | ||
| MOONLAKE IMMUNOTHERAPEUTICS | CLASS A ORD | 61559X104 | 1,096,699,739 | 21,751,284 | SH | DFND | 1 | 0 | 21,751,284 | 0 | ||
| NEWAMSTERDAM PHARMA COMPANY | ORDINARY SHARES | N62509109 | 25,264,337 | 1,521,948 | SH | DFND | 1 | 0 | 1,521,948 | 0 | ||
| NLS PHARMACEUTICS LTD | COM NEW | H57830137 | 728,437 | 143,676 | SH | DFND | 1 | 0 | 143,676 | 0 | ||
| OLEMA PHARMACEUTICALS INC | COM | 68062P106 | 109,082,562 | 9,135,893 | SH | DFND | 1 | 0 | 9,135,893 | 0 | ||
| OVID THERAPEUTICS INC | COM | 690469101 | 4,547,505 | 3,853,818 | SH | DFND | 1 | 0 | 3,853,818 | 0 | ||
| PIERIS PHARMACEUTICALS INC | COM NEW | 720795202 | 4,312,659 | 257,626 | SH | DFND | 1 | 0 | 257,626 | 0 | ||
| PROTAGONIST THERAPEUTICS INC | COM | 74366E102 | 83,257,515 | 1,850,167 | SH | DFND | 1 | 0 | 1,850,167 | 0 | ||
| REPARE THERAPEUTICS INC | COM | 760273102 | 35,547,584 | 10,333,600 | SH | DFND | 1 | 0 | 10,333,600 | 0 | ||
| REVOLUTION MEDICINES INC | COM | 76155X100 | 157,755,054 | 3,478,612 | SH | DFND | 1 | 0 | 3,478,612 | 0 | ||
| SAB BIOTHERAPEUTICS INC | COM NEW | 78397T202 | 2,478,130 | 917,826 | SH | DFND | 1 | 0 | 917,826 | 0 | ||
| STRUCTURE THERAPEUTICS INC | SPONSORED ADS | 86366E106 | 98,269,096 | 2,238,986 | SH | DFND | 1 | 0 | 2,238,986 | 0 | ||
| TENAX THERAPEUTICS INC | COM NEW | 88032L605 | 1,174,840 | 339,549 | SH | DFND | 1 | 0 | 339,549 | 0 | ||
| THIRD HARMONIC BIO INC | COM | 88427A107 | 59,158,392 | 4,365,933 | SH | DFND | 1 | 0 | 4,365,933 | 0 | ||
| TSCAN THERAPEUTICS INC | COM | 89854M101 | 14,887,581 | 2,989,474 | SH | DFND | 1 | 0 | 2,989,474 | 0 | ||
| TYRA BIOSCIENCES INC | COM | 90240B106 | 109,584,671 | 4,661,194 | SH | DFND | 1 | 0 | 4,661,194 | 0 | ||
| VERASTEM INC | COM NEW | 92337C203 | 5,038,805 | 1,685,219 | SH | DFND | 1 | 0 | 1,685,219 | 0 | ||
| VERVE THERAPEUTICS INC | COM | 92539P101 | 3,146,000 | 650,000 | SH | DFND | 1 | 0 | 650,000 | 0 | ||
| VIGIL NEUROSCIENCE INC | COM | 92673K108 | 6,166,352 | 1,813,633 | SH | DFND | 1 | 0 | 1,813,633 | 0 | ||
| VISTAGEN THERAPEUTICS INC | COM | 92840H400 | 6,020,000 | 2,000,000 | SH | DFND | 1 | 0 | 2,000,000 | 0 | ||
| XENCOR INC | COM | 98401F105 | 17,093,500 | 850,000 | SH | DFND | 1 | 0 | 850,000 | 0 | ||
| XOMA ROYALTY CORPORATION | COM NEW | 98419J206 | 96,221,515 | 3,633,743 | SH | DFND | 1 | 0 | 3,633,743 | 0 | ||
| ZYMEWORKS INC | COM | 98985Y108 | 57,829,584 | 4,607,935 | SH | DFND | 1 | 0 | 4,607,935 | 0 | ||