The Securities and Exchange Commission has not necessarily reviewed the information in this filing and has not determined if it is accurate and complete.
The reader should not assume that the information is accurate and complete.

UNITED STATES SECURITIES AND EXCHANGE COMMISSION
Washington, D.C. 20549
FORM 13F

FORM 13F INFORMATION TABLE
OMB APPROVAL
OMB Number: 3235-0006
Estimated average burden
hours per response: 23.8
COLUMN 1 COLUMN 2 COLUMN 3 COLUMN 4 COLUMN 5 COLUMN 6 COLUMN 7 COLUMN 8
VALUE SHRS OR SH/ PUT/ INVESTMENT OTHER VOTING AUTHORITY
NAME OF ISSUER TITLE OF CLASS CUSIP (x$1000) PRN AMT PRN CALL DISCRETION MANAGER SOLE SHARED NONE
10X GENOMICS INC CL A COM 88025U109 48 332 SH   DFND   0 0 332
908 DEVICES INC COM 65443P102 48 1,473 SH   DFND   0 0 1,473
ABBOTT LABS COM 002824100 61 516 SH   DFND   0 0 516
ABBVIE INC COM 00287Y109 58 539 SH   DFND   0 0 539
ACCELERATE DIAGNOSTICS INC COM 00430H102 18 3,164 SH   DFND   0 0 3,164
ACTIVISION BLIZZARD INC COM 00507V109 12 149 SH   DFND   0 0 149
ACUITY BRANDS INC COM 00508Y102 11 65 SH   DFND   0 0 65
ADAPTIMMUNE THERAPEUTICS PLC SPONDS ADR 00653A107 69 13,333 SH   DFND   0 0 13,333
ADAPTIVE BIOTECHNOLOGIES COR COM 00650F109 12 354 SH   DFND   0 0 354
ADOBE SYSTEMS INCORPORATED COM 00724F101 193 336 SH   DFND   0 0 336
ADVANCE AUTO PARTS INC COM 00751Y106 103 495 SH   DFND   0 0 495
ADVANCED DRAIN SYS INC DEL COM 00790R104 17 156 SH   DFND   0 0 156
AEROVIRONMENT INC COM 008073108 48 559 SH   DFND   0 0 559
AFYA LTD CL A COM G01125106 3,989 202,068 SH   DFND   0 0 202,068
AGILENT TECHNOLOGIES INC COM 00846U101 113 719 SH   DFND   0 0 719
AGILYSYS INC COM 00847J105 59 1,136 SH   DFND   0 0 1,136
AIR PRODS & CHEMS INC COM 009158106 103 404 SH   DFND   0 0 404
ALIBABA GROUP HLDG LTD SPONSORED ADS 01609W102 14,455 97,638 SH   DFND   0 0 97,638
ALLSTATE CORP COM 020002101 127 997 SH   DFND   0 0 997
ALNYLAM PHARMACEUTICALS INC COM 02043Q107 141 746 SH   DFND   0 0 746
ALPHABET INC CAP STK CL A 02079K305 22,131 8,278 SH   DFND   174 0 8,104
ALPHABET INC CAP STK CL C 02079K107 9,984 3,746 SH   DFND   0 0 3,746
AMAZON COM INC COM 023135106 27,765 8,452 SH   DFND   671 0 7,781
AMBARELLA INC SHS G037AX101 100 641 SH   DFND   0 0 641
AMBEV SA SPONSORED ADR 02319V103 13,307 4,821,212 SH   DFND   0 0 4,821,212
AMCOR PLC ORD G0250X107 99 8,569 SH   DFND   0 0 8,569
AMERICA MOVIL SAB DE CV SPON ADR L SHS 02364W105 32,444 1,836,109 SH   DFND   0 0 1,836,109
AMERICAN WTR WKS CO INC NEW COM 030420103 57 340 SH   DFND   0 0 340
AMGEN INC COM 031162100 51 242 SH   DFND   0 0 242
AMKOR TECHNOLOGY INC COM 031652100 81 3,254 SH   DFND   0 0 3,254
ANTHEM INC COM 036752103 11 30 SH   DFND   0 0 30
APPLE INC COM 037833100 17,717 125,210 SH   DFND   483 0 124,727
APPLIED MATLS INC COM 038222105 16 124 SH   DFND   0 0 124
ARCOS DORADOS HOLDINGS INC SHS CLASS -A - G0457F107 0 1 SH   DFND   0 0 1
ARCTURUS THERAPEUTICS HLDGS COM 03969T109 88 1,834 SH   DFND   0 0 1,834
ARMSTRONG WORLD INDS INC NEW COM 04247X102 12 122 SH   DFND   0 0 122
ARROWHEAD PHARMACEUTICALS IN COM 04280A100 20 316 SH   DFND   0 0 316
ASANA INC CL A 04342Y104 158 1,519 SH   DFND   0 0 1,519
ASENSUS SURGICAL INC COM COM 04367G103 39 20,812 SH   DFND   0 0 20,812
ASTRAZENECA PLC SPONSORED ADR 046353108 2,020 33,638 SH   DFND   0 0 33,638
AUTONATION INC COM 05329W102 92 759 SH   DFND   0 0 759
BAIDU INC SPON ADR REP A 056752108 14,812 96,338 SH   DFND   0 0 96,338
BALLARD PWR SYS INC NEW COM 058586108 168 11,970 SH   DFND   0 0 11,970
BANCO BRADESCO S A SP ADR PFD NEW 059460303 31,515 8,228,514 SH   DFND   0 0 8,228,514
BANCO SANTANDER CHILE NEW SP ADR REP COM 05965X109 2,636 133,332 SH   DFND   0 0 133,332
BANCO SANTANDER MEXICO AS SPONSORED ADS B 05969B103 1,155 201,493 SH   DFND   0 0 201,493
BERKSHIRE HATHAWAY INC DEL CL B NEW 084670702 231 847 SH   DFND   0 0 847
BEST BUY INC COM 086516101 3,489 33,005 SH   DFND   33,005 0 0
BIGCOMMERCE HLDGS INC COM SER 1 08975P108 53 1,055 SH   DFND   0 0 1,055
BIO RAD LABS INC CL A 090572207 22 29 SH   DFND   0 0 29
BIO TECHNE CORP COM 09073M104 71 147 SH   DFND   0 0 147
BIOGEN INC COM 09062X103 63 222 SH   DFND   0 0 222
BIOMARIN PHARMACEUTICAL INC COM 09061G101 49 633 SH   DFND   0 0 633
BIT MINING LIMITED SPON ADR REP A 055474100 64 7,845 SH   DFND   0 0 7,845
BLOOM ENERGY CORP COM CL A 093712107 116 6,207 SH   DFND   0 0 6,207
BLOOMIN BRANDS INC COM 094235108 427 17,085 SH   DFND   0 0 17,085
BLUEPRINT MEDICINES CORP COM 09627Y109 22 216 SH   DFND   0 0 216
BOOKING HOLDINGS INC COM 09857L108 4,980 2,098 SH   DFND   0 0 2,098
BOSTON PROPERTIES INC COM 101121101 25 232 SH   DFND   0 0 232
BOSTON SCIENTIFIC CORP COM 101137107 69 1,588 SH   DFND   0 0 1,588
BOYD GAMING CORP COM 103304101 1,455 22,993 SH   DFND   0 0 22,993
BP PLC SPONSORED ADR 055622104 1,662 60,800 SH   DFND   0 0 60,800
BRF SA SPONSORED ADR 10552T107 3,550 707,213 SH   DFND   707,213 0 0
BRISTOL MYERS SQUIBB CO COM 110122108 137 2,308 SH   DFND   0 0 2,308
BRUKER CORP COM 116794108 23 298 SH   DFND   0 0 298
CAESARS ENTERTAINMENT INC NE COM 12769G100 1,078 9,599 SH   DFND   0 0 9,599
CANADIAN PAC RY LTD COM 13645T100 73 1,115 SH   DFND   0 0 1,115
CAPITAL ONE FINL CORP COM 14040H105 175 1,080 SH   DFND   0 0 1,080
CAREDX INC COM 14167L103 16 252 SH   DFND   0 0 252
CATALENT INC COM 148806102 64 482 SH   DFND   0 0 482
CEMEX SAB DE CV SPON ADR NEW 151290889 28,529 3,978,920 SH   DFND   0 0 3,978,920
CHARGEPOINT HOLDINGS INC COM CL A 15961R105 44 2,209 SH   DFND   0 0 2,209
CHARLES RIV LABS INTL INC COM 159864107 92 224 SH   DFND   0 0 224
CHART INDS INC COM PAR $0.01 16115Q308 151 788 SH   DFND   0 0 788
CHARTER COMMUNICATIONS INC N CL A 16119P108 97 134 SH   DFND   0 0 134
CHEMOURS CO COM 163851108 82 2,823 SH   DFND   0 0 2,823
CHEVRON CORP NEW COM 166764100 7,609 75,000 SH   DFND   0 0 75,000
CISCO SYS INC COM 17275R102 203 3,733 SH   DFND   0 0 3,733
CITRIX SYS INC COM 177376100 32 294 SH   DFND   0 0 294
CLEAN HARBORS INC COM 184496107 11 106 SH   DFND   0 0 106
CME GROUP INC COM CL A 12572Q105 1,122 5,800 SH   DFND   0 0 5,800
COCA COLA CO COM 191216100 3,041 57,957 SH   DFND   0 0 57,957
COGNIZANT TECHNOLOGY SOLUTIO CL A 192446102 52 695 SH   DFND   0 0 695
COINBASE GLOBAL INC COM CL A 19260Q107 323 1,420 SH   DFND   1,420 0 0
COLFAX CORP COM 194014106 71 1,539 SH   DFND   0 0 1,539
COLGATE PALMOLIVE CO COM 194162103 99 1,311 SH   DFND   0 0 1,311
COMCAST CORP NEW CL A 20030N101 63 1,130 SH   DFND   0 0 1,130
COMPANHIA ENERGETICA DE MINA SP ADR N-V PFD 204409601 27 10,762 SH   DFND   10,762 0 0
CONSOLIDATED EDISON INC COM 209115104 28 381 SH   DFND   0 0 381
CORTEVA INC COM 22052L104 162 3,856 SH   DFND   0 0 3,856
COSTCO WHSL CORP NEW COM 22160K105 24,022 53,459 SH   DFND   0 0 53,459
CREDICORP LTD COM G2519Y108 13,636 122,913 SH   DFND   0 0 122,913
CREE INC COM 225447101 28 348 SH   DFND   0 0 348
CRISPR THERAPEUTICS AG NAMEN AKT H17182108 90 807 SH   DFND   0 0 807
CUMMINS INC COM 231021106 103 457 SH   DFND   0 0 457
D R HORTON INC COM 23331A109 111 1,323 SH   DFND   0 0 1,323
DANAHER CORP DEL COM 235851102 389 1,278 SH   DFND   0 0 1,278
DARLING INGREDIENTS INC COM 237266101 31 438 SH   DFND   0 0 438
DELTA AIR LINES INC DEL COM NEW 247361702 1,065 25,000 SH   DFND   0 0 25,000
DENALI THERAPEUTICS INC COM 24823R105 19 379 SH   DFND   0 0 379
DESKTOP METAL INC COM CL A 25058X105 33 4,642 SH   DFND   0 0 4,642
DEXCOM INC COM 252131107 85 155 SH   DFND   0 0 155
DISCOVER FINL SVCS COM 254709108 133 1,080 SH   DFND   0 0 1,080
DISNEY WALT CO COM DISNEY 254687106 36,608 216,399 SH   DFND   2,701 0 213,698
DLOCAL LTD CLASS A COM COM G29018101 10,310 188,965 SH   DFND   0 0 188,965
DUPONT DE NEMOURS INC COM 26614N102 60 878 SH   DFND   0 0 878
DUTCH BROS INC CL A 26701L100 4,918 113,519 SH   DFND   0 0 113,519
EATON CORP PLC SHS G29183103 80 535 SH   DFND   0 0 535
EBANG INTL HLDGS INC CL A SHS G3R33A106 32 16,914 SH   DFND   0 0 16,914
EDWARDS LIFESCIENCES CORP COM 28176E108 73 648 SH   DFND   0 0 648
ELECTRAMECCANICA VEHS CORP COM NEW 284849205 46 12,981 SH   DFND   0 0 12,981
EMBRAER S A SP ADR REP 4 COM 29082A107 4,287 252,149 SH   DFND   0 0 252,149
ENERGY RECOVERY INC COM 29270J100 59 3,103 SH   DFND   0 0 3,103
ENPHASE ENERGY INC COM 29355A107 52 348 SH   DFND   0 0 348
ENTEGRIS INC COM 29362U104 27 212 SH   DFND   0 0 212
EOS ENERGY ENTERPRISES INC COM CL A 29415C101 47 3,328 SH   DFND   0 0 3,328
ESSENTIAL UTILS INC COM 29670G102 20 433 SH   DFND   0 0 433
EXACT SCIENCES CORP COM 30063P105 48 500 SH   DFND   0 0 500
EXELIXIS INC COM 30161Q104 72 3,419 SH   DFND   0 0 3,419
EXPEDIA GROUP INC COM NEW 30212P303 5,875 35,847 SH   DFND   0 0 35,847
F M C CORP COM NEW 302491303 88 11,706 SH   DFND   0 0 11,706
F5 NETWORKS INC COM 315616102 65 329 SH   DFND   0 0 329
FACEBOOK INC CL A 30303M102 50,010 147,354 SH   DFND   0 0 147,354
FATE THERAPEUTICS INC COM 31189P102 17 279 SH   DFND   0 0 279
FIDELITY NATL INFORMATION SV COM 31620M106 74 612 SH   DFND   0 0 612
FIRST SOLAR INC COM 336433107 27 280 SH   DFND   0 0 280
FISERV INC COM 337738108 16 150 SH   DFND   0 0 150
FOMENTO ECONOMICO MEXICANO S SPON ADR UNITS 344419106 21,103 243,348 SH   DFND   0 0 243,348
FOOT LOCKER INC COM 344849104 464 10,172 SH   DFND   0 0 10,172
FORGEROCK INC CL A 34631B101 1,280 32,882 SH   DFND   0 0 32,882
FREEPORT-MCMORAN INC CL B 35671D857 13,000 399,637 SH   DFND   0 0 399,637
FUELCELL ENERGY INC COM 35952H601 102 15,311 SH   DFND   0 0 15,311
GENERAL ELECTRIC CO COM 369604301 67 651 SH   DFND   0 0 651
GENERAL MTRS CO COM 37045V100 180 3,420 SH   DFND   0 0 3,420
GERDAU SA SPON ADR REP PFD 373737105 21,841 4,439,290 SH   DFND   0 0 4,439,290
GILEAD SCIENCES INC COM 375558103 477 6,828 SH   DFND   5,875 0 953
GLOBAL X FDS LITHIUM BTRY ETF 37954Y855 5,983 73,000 SH   DFND   0 0 73,000
GLOBANT S A COM L44385109 32,721 116,439 SH   DFND   0 0 116,439
GRAPHIC PACKAGING HLDG CO COM 388689101 14 710 SH   DFND   0 0 710
GRUPO AEROPORTUARIO DEL SURE SPON ADR SER B 40051E202 9,196 49,178 SH   DFND   0 0 49,178
GRUPO TELEVISA SA SPON ADR REP ORD 40049J206 7,817 711,973 SH   DFND   0 0 711,973
GUARDANT HEALTH INC COM 40131M109 52 415 SH   DFND   0 0 415
HEXCEL CORP NEW COM 428291108 11 177 SH   DFND   0 0 177
HILTON WORLDWIDE HLDGS INC COM 43300A203 82 622 SH   DFND   0 0 622
HOLOGIC INC COM 436440101 80 1,078 SH   DFND   0 0 1,078
HUMANA INC COM 444859102 9 22 SH   DFND   0 0 22
HYSTER YALE MATLS HANDLING I CL A 449172105 79 1,580 SH   DFND   0 0 1,580
IDACORP INC COM 451107106 10 101 SH   DFND   0 0 101
ILLUMINA INC COM 452327109 159 391 SH   DFND   0 0 391
IMMUNITYBIO INC COM 45256X103 40 4,065 SH   DFND   0 0 4,065
INCYTE CORP COM 45337C102 63 919 SH   DFND   0 0 919
INFOSYS LTD SPONSORED ADR 456788108 604 27,151 SH   DFND   0 0 27,151
INOVIO PHARMACEUTICALS INC COM NEW 45773H201 45 6,234 SH   DFND   0 0 6,234
INSULET CORP COM 45784P101 66 231 SH   DFND   0 0 231
INTEGRA LIFESCIENCES HLDGS C COM NEW 457985208 14 203 SH   DFND   0 0 203
INTELLIA THERAPEUTICS INC COM 45826J105 40 296 SH   DFND   0 0 296
INTERCONTINENTAL EXCHANGE IN COM 45866F104 1,943 16,920 SH   DFND   0 0 16,920
INTL PAPER CO COM 460146103 49 876 SH   DFND   0 0 876
INTUITIVE SURGICAL INC COM NEW 46120E602 71 71 SH   DFND   0 0 71
INVITAE CORP COM 46185L103 20 702 SH   DFND   0 0 702
IONIS PHARMACEUTICALS INC COM 462222100 42 1,241 SH   DFND   0 0 1,241
IQVIA HLDGS INC COM 46266C105 173 722 SH   DFND   0 0 722
IROBOT CORP COM 462726100 51 650 SH   DFND   0 0 650
ISHARES INC CALL 464286900 59 1,500 SH Call DFND   0 0 1,500
ISHARES INC MSCI BRAZIL ETF 464286400 1,445 44,980 SH   DFND   0 0 44,980
ISHARES INC MSCI JPN ETF NEW 46434G822 5,755 81,920 SH   DFND   0 0 81,920
ISHARES INC PUT 464286950 2,843 1,500 SH Put DFND   0 0 1,500
ISHARES INC MSCI PAC JP ETF 464286665 332 6,800 SH   DFND   0 0 6,800
ISHARES INC MSCI CDA ETF 464286509 3,567 98,270 SH   DFND   0 0 98,270
ISHARES INC MSCI STH KOR ETF 464286772 1,976 24,500 SH   DFND   0 0 24,500
ISHARES INC CORE MSCI EMKT 46434G103 667 10,800 SH   DFND   0 0 10,800
ISHARES INC MSCI EM ASIA ETF 464286426 1,604 19,000 SH   DFND   0 0 19,000
ISHARES INC MSCI GERMANY ETF 464286806 34 1,032 SH   DFND   0 0 1,032
ISHARES TR CALL 464287904 40 250 SH Call DFND   0 0 250
ISHARES TR CHINA LG-CAP ETF 464287184 12,213 313,715 SH   DFND   0 0 313,715
ISHARES TR MSCI EAFE ETF 464287465 12,154 155,800 SH   DFND   0 0 155,800
ISHARES TR MSCI EMG MKT ETF 464287234 4,299 85,331 SH   DFND   0 0 85,331
ISHARES TR RUSSELL 2000 ETF 464287655 2,253 10,301 SH   DFND   0 0 10,301
ISHARES TR MSCI ACWI ETF 464288257 4,347 43,500 SH   DFND   0 0 43,500
ISHARES TR MSCI CHINA ETF 46429B671 3,241 48,000 SH   DFND   0 0 48,000
ISHARES TR JPMORGAN USD EMG 464288281 1,651 15,000 SH   DFND   0 0 15,000
ISHARES TR IBOXX INV CP ETF 464287242 2,488 18,700 SH   DFND   0 0 18,700
ISHARES TR S&P 500 VAL ETF 464287408 4,290 29,500 SH   DFND   0 0 29,500
ISHARES TR TIPS BD ETF 464287176 4,577 94,000 SH   DFND   0 0 94,000
ISHARES TR RUS 1000 VAL ETF 464287598 7,674 49,035 SH   DFND   0 0 49,035
ITAU UNIBANCO HLDG S A SPON ADR REP PFD 465562106 50,898 9,658,135 SH   DFND   0 0 9,658,135
JAZZ PHARMACEUTICALS PLC SHS USD G50871105 49 374 SH   DFND   0 0 374
JOHNSON & JOHNSON COM 478160104 7,396 45,798 SH   DFND   2,762 0 43,036
JUNIPER NETWORKS INC COM 48203R104 60 2,195 SH   DFND   0 0 2,195
KANSAS CITY SOUTHERN COM NEW 485170302 58 215 SH   DFND   0 0 215
KKR & CO INC CL A 48251W104 5,731 94,135 SH   DFND   0 0 94,135
KRANESHARES TR CSI CHI INTERNET 500767306 13,999 295,837 SH   DFND   0 0 295,837
L3HARRIS TECHNOLOGIES INC COM 502431109 99 449 SH   DFND   0 0 449
LABORATORY CORP AMER HLDGS COM NEW 50540R409 284 1,008 SH   DFND   0 0 1,008
LAUDER ESTEE COS INC CL A 518439104 1,107 3,690 SH   DFND   0 0 3,690
LENDINGCLUB CORP COM NEW 52603A208 108 3,826 SH   DFND   0 0 3,826
LENNAR CORP CL A 526057104 111 1,185 SH   DFND   0 0 1,185
LILLY ELI & CO COM 532457108 75 324 SH   DFND   0 0 324
LINDE PLC COM G5494J103 219 748 SH   DFND   0 0 748
LIVANOVA PLC SHS G5509L101 65 822 SH   DFND   0 0 822
LOUISIANA PAC CORP COM 546347105 12 201 SH   DFND   0 0 201
LOWES COS INC COM 548661107 174 858 SH   DFND   0 0 858
LULULEMON ATHLETICA INC COM 550021109 20 49 SH   DFND   0 0 49
LUMINAR TECHNOLOGIES INC COM CL A 550424105 40 2,559 SH   DFND   0 0 2,559
LUXFER HOLDINGS PLC SHS G5698W116 37 1,895 SH   DFND   0 0 1,895
LYONDELLBASELL INDUSTRIES N SHS - A - N53745100 122 1,300 SH   DFND   0 0 1,300
MARAVAI LIFESCIENCES HLDGS I COM CL A 56600D107 21 435 SH   DFND   0 0 435
MASCO CORP COM 574599106 24 437 SH   DFND   0 0 437
MASTERCARD INCORPORATED CL A 57636Q104 103 296 SH   DFND   0 0 296
MATCH GROUP INC NEW COM 57667L107 17 111 SH   DFND   0 0 111
MCAFEE CORP COM CL A 579063108 1,067 48,249 SH   DFND   0 0 48,249
MEDPACE HLDGS INC COM 58506Q109 26 139 SH   DFND   0 0 139
MEDTRONIC PLC SHS G5960L103 60 482 SH   DFND   0 0 482
MERCADOLIBRE INC COM 58733R102 17,933 10,678 SH   DFND   0 0 10,678
MERCK & CO INC COM 58933Y105 56 743 SH   DFND   0 0 743
MERCURY SYS INC COM 589378108 45 946 SH   DFND   0 0 946
METLIFE INC COM 59156R108 162 2,620 SH   DFND   0 0 2,620
MICRON TECHNOLOGY INC COM 595112103 574 8,091 SH   DFND   0 0 8,091
MICROSOFT CORP COM 594918104 31,549 111,907 SH   DFND   6,288 0 105,619
MICROVISION INC DEL COM NEW 594960304 33 2,942 SH   DFND   0 0 2,942
MIRATI THERAPEUTICS INC COM 60468T105 30 172 SH   DFND   0 0 172
MODERNA INC COM 60770K107 307 798 SH   DFND   0 0 798
MOHAWK INDS INC COM 608190104 13 75 SH   DFND   0 0 75
MONDELEZ INTL INC CL A 609207105 22 372 SH   DFND   0 0 372
MONGODB INC CL A 60937P106 88 187 SH   DFND   0 0 187
MOODYS CORP COM 615369105 665 1,874 SH   DFND   0 0 1,874
MORGAN STANLEY COM NEW 617446448 2,919 30,000 SH   DFND   0 0 30,000
NANO DIMENSION LTD SPONSORD ADS NEW 63008G203 45 7,914 SH   DFND   0 0 7,914
NATERA INC COM 632307104 38 342 SH   DFND   0 0 342
NATURA &CO HLDG S A ADS 63884N108 4,274 256,686 SH   DFND   0 0 256,686
NEKTAR THERAPEUTICS COM 640268108 54 3,002 SH   DFND   0 0 3,002
NEOGENOMICS INC COM NEW 64049M209 20 422 SH   DFND   0 0 422
NETFLIX INC COM 64110L106 17,431 28,560 SH   DFND   2,183 0 26,377
NETSCOUT SYS INC COM 64115T104 56 2,075 SH   DFND   0 0 2,075
NEUROCRINE BIOSCIENCES INC COM 64125C109 19 203 SH   DFND   0 0 203
NEXTERA ENERGY INC COM 65339F101 1,723 21,940 SH   DFND   21,940 0 0
NIKE INC CL B 654106103 9,059 62,380 SH   DFND   228 0 62,152
NIKOLA CORP COM 654110105 138 12,967 SH   DFND   0 0 12,967
NOVAVAX INC COM NEW 670002401 37 177 SH   DFND   0 0 177
NVIDIA CORP COM 67066G104 15,778 76,162 SH   DFND   4,152 0 72,010
NXP SEMICONDUCTORS N V COM N6596X109 7,450 38,036 SH   DFND   0 0 38,036
OLIN CORP COM PAR $1 680665205 125 2,588 SH   DFND   0 0 2,588
ON SEMICONDUCTOR CORP COM 682189105 36 789 SH   DFND   0 0 789
ONECONNECT FINL TECHNOLOGY C SPONSORD ADS 68248T105 20 4,927 SH   DFND   0 0 4,927
ORCHARD THERAPEUTICS PLC ADS 68570P101 27 11,609 SH   DFND   0 0 11,609
OTIS WORLDWIDE CORP COM 68902V107 94 1,146 SH   DFND   0 0 1,146
OWENS CORNING NEW COM 690742101 11 133 SH   DFND   0 0 133
PACIFIC BIOSCIENCES CALIF IN COM 69404D108 22 856 SH   DFND   0 0 856
PAGSEGURO DIGITAL LTD COM CL A G68707101 3,588 69,372 SH   DFND   0 0 69,372
PALO ALTO NETWORKS INC COM 697435105 1,553 3,243 SH   DFND   0 0 3,243
PAYPAL HLDGS INC COM 70450Y103 1,715 6,590 SH   DFND   751 0 5,839
PENTAIR PLC SHS G7S00T104 22 303 SH   DFND   0 0 303
PEPSICO INC COM 713448108 45 296 SH   DFND   0 0 296
PERKINELMER INC COM 714046109 112 647 SH   DFND   0 0 647
PETROLEO BRASILEIRO SA PETRO PUT 71654V958 1,085 1,865 SH Put DFND   0 0 1,865
PETROLEO BRASILEIRO SA PETRO SP ADR NON VTG 71654V101 24,396 2,439,612 SH   DFND   1,944,756 0 494,856
PETROLEO BRASILEIRO SA PETRO SPONSORED ADR 71654V408 44,122 4,267,128 SH   DFND   333,181 0 3,933,947
PFIZER INC COM 717081103 290 6,735 SH   DFND   0 0 6,735
PLUG POWER INC COM NEW 72919P202 158 6,201 SH   DFND   0 0 6,201
POLARIS INDS INC COM 731068102 14 116 SH   DFND   0 0 116
PPD INC COM 69355F102 24 513 SH   DFND   0 0 513
PROCAPS GROUP S A SHS L7756P102 1,224 120,000 SH   DFND   0 0 120,000
PROCTER AND GAMBLE CO COM 742718109 142 1,019 SH   DFND   0 0 1,019
PROQR THRAPEUTICS N V SHS EURO N71542109 79 9,479 SH   DFND   0 0 9,479
QUALCOMM INC COM 747525103 31 238 SH   DFND   0 0 238
QUEST DIAGNOSTICS INC COM 74834L100 196 1,349 SH   DFND   0 0 1,349
QUIDEL CORP COM 74838J101 26 184 SH   DFND   0 0 184
RADWARE LTD ORD M81873107 71 2,106 SH   DFND   0 0 2,106
RAYONIER INC COM 754907103 10 271 SH   DFND   0 0 271
REGENERON PHARMACEUTICALS COM 75886F107 337 557 SH   DFND   0 0 557
REPLIGEN CORP COM 759916109 55 192 SH   DFND   0 0 192
REPUBLIC SVCS INC COM 760759100 49 406 SH   DFND   0 0 406
RIDGEBIO PHARMA INC COM COM 10806X102 9 185 SH   DFND   0 0 185
ROKU INC COM CL A 77543R102 12 38 SH   DFND   0 0 38
ROMEO POWER INC COM 776153108 31 6,328 SH   DFND   0 0 6,328
ROPER TECHNOLOGIES INC COM 776696106 12,313 27,600 SH   DFND   0 0 27,600
ROSS STORES INC COM 778296103 1,985 18,240 SH   DFND   0 0 18,240
ROYAL DUTCH SHELL PLC SPONS ADR A 780259206 107 2,390 SH   DFND   0 0 2,390
SALESFORCE COM INC COM 79466L302 4,163 15,348 SH   DFND   0 0 15,348
SAREPTA THERAPEUTICS INC COM 803607100 18 191 SH   DFND   0 0 191
SCHWAB CHARLES CORP NEW COM 808513105 1,275 17,500 SH   DFND   0 0 17,500
SEA LTD ADR 81141R100 9,739 30,556 SH   DFND   0 0 30,556
SEAGATE TECHNOLOGY HLDNGS PL COM G7997R103 75 909 SH   DFND   0 0 909
SEAGEN INC COM 81181C104 48 280 SH   DFND   0 0 280
SELECT SECTOR SPDR TR CALL 81369Y906 185 1,000 SH Call DFND   0 0 1,000
SELECT SECTOR SPDR TR CALL 81369Y905 0 1 SH   DFND   0 0 1
SELECT SECTOR SPDR TR ENERGY 81369Y506 10,910 209,442 SH   DFND   0 0 209,442
SELECT SECTOR SPDR TR SBI INT-FINL 81369Y605 27,305 727,554 SH   DFND   0 0 727,554
SELECT SECTOR SPDR TR TECHNOLOGY 81369Y803 14,264 95,528 SH   DFND   0 0 95,528
SELECT SECTOR SPDR TR SBI INT-UTILS 81369Y886 762 11,924 SH   DFND   0 0 11,924
SELECT SECTOR SPDR TR SBI INT-INDS 81369Y704 22,604 231,030 SH   DFND   0 0 231,030
SELECT SECTOR SPDR TR SBI MATERIALS 81369Y100 14,912 188,500 SH   DFND   0 0 188,500
SELECT SECTOR SPDR TR RL EST SEL SEC 81369Y860 7,120 160,180 SH   DFND   0 0 160,180
SERVICENOW INC COM 81762P102 53 85 SH   DFND   0 0 85
SHERWIN WILLIAMS CO COM 824348106 98 350 SH   DFND   0 0 350
SILICON LABORATORIES INC COM 826919102 64 459 SH   DFND   0 0 459
SL GREEN RLTY CORP COM 78440X804 9 131 SH   DFND   0 0 131
SMUCKER J M CO COM NEW 832696405 95 792 SH   DFND   0 0 792
SOCIEDAD QUIMICA MINERA DE C SPON ADR SER B 833635105 7,951 148,000 SH   DFND   0 0 148,000
SOHU COM LTD SPONSORED ADS 83410S108 76 3,631 SH   DFND   0 0 3,631
SONY CORP SPONSORED ADR 835699307 536 4,844 SH   DFND   0 0 4,844
SOUTHWEST AIRLS CO COM 844741108 2,422 47,094 SH   DFND   0 0 47,094
SPDR GOLD TR GOLD SHS 78463V107 3,148 19,167 SH   DFND   0 0 19,167
SPDR INDEX SHS FDS ASIA PACIF ETF 78463X301 2,544 20,500 SH   DFND   0 0 20,500
SPDR S&P 500 ETF TR PUT 78462F953 2,609 5,943 SH Put DFND   0 0 5,943
SPDR SER TR S&P OILGAS EXP 78468R556 8,850 91,500 SH   DFND   0 0 91,500
STARBUCKS CORP COM 855244109 3,116 28,245 SH   DFND   0 0 28,245
STEEL DYNAMICS INC COM 858119100 27 463 SH   DFND   0 0 463
STELLANTIS N.V COM N82405106 156 8,181 SH   DFND   0 0 8,181
STERICYCLE INC COM 858912108 10 151 SH   DFND   0 0 151
STERLING CHECK CORP COM 85917T109 2,715 104,589 SH   DFND   0 0 104,589
SUNRUN INC COM 86771W105 17 386 SH   DFND   0 0 386
SUPER LEAGUE GAMING INC COM 86804F202 34 10,866 SH   DFND   0 0 10,866
SUZANO S A SPON COM 86959K105 10,743 1,074,345 SH   DFND   0 0 1,074,345
SYNCHRONY FINL COM 87165B103 121 2,474 SH   DFND   0 0 2,474
SYNEOS HEALTH INC CL A 87166B102 71 815 SH   DFND   0 0 815
SYNOPSYS INC COM 871607107 107 359 SH   DFND   0 0 359
T MOBILE US INC COM 872590104 140 1,096 SH   DFND   0 0 1,096
TAIWAN SEMICONDUCTOR MFG LTD SPONSORED ADR 874039100 296 2,648 SH   DFND   0 0 2,648
TARGET CORP COM 87612E106 90 392 SH   DFND   0 0 392
TELADOC HEALTH INC COM 87918A105 82 647 SH   DFND   0 0 647
TENET HEALTHCARE CORP COM NEW 88033G407 93 1,398 SH   DFND   0 0 1,398
TESLA INC COM 88160R101 15,805 20,381 SH   DFND   0 0 20,381
TG THERAPEUTICS INC COM 88322Q108 14 407 SH   DFND   0 0 407
THERMO FISHER SCIENTIFIC INC COM 883556102 186 325 SH   DFND   0 0 325
TIM S A COM 88706T108 4,958 461,661 SH   DFND   0 0 461,661
TOAST INC CL A 888787108 2,607 52,200 SH   DFND   0 0 52,200
TOPBUILD CORP COM 89055F103 14 67 SH   DFND   0 0 67
TREX CO INC COM 89531P105 31 305 SH   DFND   0 0 305
TWILIO INC CL A 90138F102 1,705 5,344 SH   DFND   0 0 5,344
TWIST BIOSCIENCE CORP COM 90184D100 23 213 SH   DFND   0 0 213
TWITTER INC COM 90184L102 15,878 262,917 SH   DFND   0 0 262,917
TYSON FOODS INC CL A 902494103 3,757 47,597 SH   DFND   0 0 47,597
UBER TECHNOLOGIES INC COM 90353T100 85 1,893 SH   DFND   0 0 1,893
ULTRAGENYX PHARMACEUTICAL IN COM 90400D108 28 309 SH   DFND   0 0 309
UNITED THERAPEUTICS CORP DEL COM 91307C102 71 383 SH   DFND   0 0 383
UNITEDHEALTH GROUP INC COM 91324P102 2,998 7,673 SH   DFND   0 0 7,673
UNIVERSAL DISPLAY CORP COM 91347P105 23 133 SH   DFND   0 0 133
US FOODS HLDG CORP COM 912008109 2,073 59,808 SH   DFND   0 0 59,808
VALE S A SPONSORED ADS 91912E105 54,408 3,900,194 SH   DFND   0 0 3,900,194
VANECK VECTORS ETF TR RUSSIA ETF 92189F403 5,154 170,000 SH   DFND   0 0 170,000
VANGUARD INDEX FDS S&P 500 ETF SHS 922908363 665,854 1,688,272 SH   DFND   0 0 1,688,272
VANGUARD INDEX FDS REAL ESTATE ETF 922908553 8,957 88,000 SH   DFND   0 0 88,000
VANGUARD INTL EQUITY INDEX F TT WRLD ST ETF 922042742 15,100 148,288 SH   DFND   0 0 148,288
VARONIS SYS INC COM 922280102 76 1,255 SH   DFND   0 0 1,255
VELODYNE LIDAR INC COM 92259F101 32 5,446 SH   DFND   0 0 5,446
VERTEX PHARMACEUTICALS INC COM 92532F100 125 689 SH   DFND   0 0 689
VICTORIAS SECRET AND CO COMMON STOCK 926400102 781 14,132 SH   DFND   0 0 14,132
VIPSHOP HLDGS LTD SPONSORED ADR 92763W103 161 14,491 SH   DFND   0 0 14,491
VIRGIN GALACTIC HOLDINGS INC COM 92766K106 45 1,778 SH   DFND   0 0 1,778
VISA INC COM CL A 92826C839 152 683 SH   DFND   0 0 683
VMWARE INC CL A COM 928563402 38 256 SH   DFND   0 0 256
VORNADO RLTY TR SH BEN INT 929042109 14 330 SH   DFND   0 0 330
VUZIX CORP COM NEW 92921W300 34 3,292 SH   DFND   0 0 3,292
WABTEC CORP COM 929740108 42 488 SH   DFND   0 0 488
WALMART INC COM 931142103 2,153 15,447 SH   DFND   0 0 15,447
WASTE MGMT INC DEL COM 94106L109 121 813 SH   DFND   0 0 813
WATERS CORP COM 941848103 79 222 SH   DFND   0 0 222
WELLS FARGO CO NEW COM 949746101 2,604 56,100 SH   DFND   0 0 56,100
WESTLAKE CHEM CORP COM 960413102 85 933 SH   DFND   0 0 933
WESTPORT FUEL SYSTEMS INC COM NEW 960908309 73 22,315 SH   DFND   0 0 22,315
WEYERHAEUSER CO COM 962166104 66 1,866 SH   DFND   0 0 1,866
WHIRLPOOL CORP COM 963320106 89 436 SH   DFND   0 0 436
WISDOMTREE TR INDIA ERNGS FD 97717W422 1,309 35,000 SH   DFND   0 0 35,000
WORKHORSE GROUP INC COM NEW 98138J206 28 3,700 SH   DFND   0 0 3,700
WORTHINGTON INDS INC COM 981811102 74 1,404 SH   DFND   0 0 1,404
XCEL ENERGY INC COM 98389B100 33 529 SH   DFND   0 0 529
XILINX INC COM 983919101 2,567 17,000 SH   DFND   0 0 17,000
XP INC CL A G98239109 3,110 77,415 SH   DFND   0 0 77,415
XPERI HOLDING CORP COM 98390M103 52 2,775 SH   DFND   0 0 2,775
XUNLEI LTD SPONSORED ADR 98419E108 34 11,788 SH   DFND   0 0 11,788
XYLEM INC COM 98419M100 37 299 SH   DFND   0 0 299
YELP INC CL A 985817105 57 1,522 SH   DFND   0 0 1,522
ZOETIS INC CL A 98978V103 3,410 17,563 SH   DFND   0 0 17,563
ZOOM VIDEO COMMUNICATIONS IN CL A 98980L101 1,019 3,897 SH   DFND   3,834 0 63