The Securities and Exchange Commission has not necessarily reviewed the information in this filing and has not determined if it is accurate and complete.
The reader should not assume that the information is accurate and complete.

UNITED STATES SECURITIES AND EXCHANGE COMMISSION
Washington, D.C. 20549
FORM 13F

FORM 13F INFORMATION TABLE
OMB APPROVAL
OMB Number: 3235-0006
Estimated average burden
hours per response: 23.8
COLUMN 1 COLUMN 2 COLUMN 3 COLUMN 4 COLUMN 5 COLUMN 6 COLUMN 7 COLUMN 8
VALUE SHRS OR SH/ PUT/ INVESTMENT OTHER VOTING AUTHORITY
NAME OF ISSUER TITLE OF CLASS CUSIP (x$1000) PRN AMT PRN CALL DISCRETION MANAGER SOLE SHARED NONE
ABILITY INC SHS G8789K124 178 312,642 SH   DFND 1 0 312,642 0
ACTINIUM PHARMACEUTICALS INC COM 00507W107 2,023 8,797,509 SH   DFND 1 0 8,797,509 0
ADAMIS PHARMACEUTICALS CORP COM 00547W958 8 114 SH Put DFND 1 0 114 0
ADAMIS PHARMACEUTICALS CORP COM 00547W208 129 183,359 SH   DFND 1 0 183,359 0
ADVAXIS INC COM 007624307 403 1,521,982 SH   DFND 1 0 1,521,982 0
AETERNA ZENTARIS INC COM 007975402 74 72,076 SH   DFND 1 0 72,076 0
AILERON THERAPEUTICS INC COM 00887A105 368 549,900 SH   DFND 1 0 549,900 0
AIM IMMUNOTECH INC COM 00901B105 141 185,171 SH   DFND 1 0 185,171 0
ALTIMMUNE INC COM COM 02155H950 26 134 SH Put DFND 1 0 134 0
ALTIMMUNE INC COM COM 02155H200 81 41,758 SH   DFND 1 0 41,758 0
AMARIN CORP ADR 023111906 2,905 1,916 SH Call DFND 1 0 1,916 0
AMARIN CORP ADR 023111956 3,482 2,297 SH Put DFND 1 0 2,297 0
AMARIN CORP ADR 023111206 470 30,990 SH   DFND 1 0 30,990 0
ARCADIA BIOSCIENCES INC COM 039014204 234 50,000 SH   DFND 1 0 50,000 0
ARCTURUS THERAPEUTICS HLDG INC COM 03969T109 1,282 124,843 SH   DFND 1 0 124,843 0
AURINIA PHARAMCEUTICALS INC COM 05156V902 896 1,677 SH Call DFND 1 0 1,677 0
AURIS MED HLDG LTD COM G07025201 461 167,500 SH   DFND 1 0 167,500 0
AVALON GLOBOCARE CORP COM 05344R104 369 197,119 SH   DFND 1 0 197,119 0
AVEO PHARMACEUTICALS INC COM COM 053588959 498 5,895 SH Put DFND 1 0 5,895 0
BELLICUM PHARMACEUTICALS INC COM 079481107 44 42,007 SH   DFND 1 0 42,007 0
BENITEC BIOPHARMA LTD *W 082053117 1 51,449 SH   DFND 1 0 51,449 0
BENITEC BIOPHARMA LTD ADR 082053307 971 1,365,615 SH   DFND 1 0 1,365,615 0
BIOHAVEN PHARMACEUTICAL HLDG CO LTD COM G11196955 1,719 412 SH Put DFND 1 0 412 0
BIOHAVEN PHARMACEUTICAL HLDG CO LTD COM G11196105 828 19,850 SH   DFND 1 0 19,850 0
BRAINSTORM CELL THERAPEUTICS INC COM 10501E951 1,016 2,606 SH Put DFND 1 0 2,606 0
BRIDGELINE DIGITAL INC COM COM 10807Q700 210 110,000 SH   DFND 1 0 110,000 0
CEL SCI CORP COM 150837907 167 187 SH Call DFND 1 0 187 0
CEL SCI CORP COM 150837957 764 855 SH Put DFND 1 0 855 0
CELSION CORP COM 15117N503 240 156,100 SH   DFND 1 0 156,100 0
CELSION CORP COM 15117N953 28 184 SH Put DFND 1 0 184 0
CELSION CORP COM 15117N903 40 260 SH Call DFND 1 0 260 0
CHINA JO-JO DRUGSTORES INC COM 16949A206 1,590 1,325,299 SH   DFND 1 0 1,325,299 0
CITIUS PHARMACEUTICALS INC COM 17322U207 640 845,432 SH   DFND 1 0 845,432 0
CORMEDIX INC COM 21900C308 1,590 249,198 SH   DFND 1 0 249,198 0
CORMEDIX INC COM 21900C958 1,235 1,936 SH Put DFND 1 0 1,936 0
CYTRX CORP COM 232828608 237 729,450 SH   DFND 1 0 729,450 0
DELMAR PHARMACEUTICALS INC COM 247078306 526 951,454 SH   DFND 1 0 951,454 0
DIFFUSION PHARMACEUTICALS INC COM 253748305 865 467,819 SH   DFND 1 0 467,819 0
ELECTRAMECCANICA VEHS CORP COM 284849205 587 288,408 SH   DFND 1 0 288,408 0
EYENOVIA INC COM 30234E104 66 17,900 SH   DFND 1 0 17,900 0
GENOCEA BIOSCIENCES INC COM 372427401 1,384 477,351 SH   DFND 1 0 477,351 0
GENOCEA BIOSCIENCES INC COM 372427901 429 1,481 SH Call DFND 1 0 1,481 0
GENPREX INC COM 372446104 462 577,323 SH   DFND 1 0 577,323 0
HEPION PHARMACEUTICALS INC COM 426897104 278 115,000 SH   DFND 1 0 115,000 0
INNOVATE BIOPHARMACEUTICLS INC COM 45782F105 1,336 1,248,814 SH   DFND 1 0 1,248,814 0
INPIXON COM 45790J503 275 2,360,220 SH   DFND 1 0 2,360,220 0
INSPIREMD INC COM 45779A853 408 313,572 SH   DFND 1 0 313,572 0
IONIS PHARMACEUTICALS INC COM 462222900 18,201 3,038 SH Call DFND 1 0 3,038 0
ISHARES TR ETF 464287955 23,881 1,578 SH Put DFND 1 0 1,578 0
ISHARES TR ETF 464287905 23,654 1,563 SH Call DFND 1 0 1,563 0
KADMON HLDGS INC COM 48283N956 321 114 SH Put DFND 1 0 114 0
MEDIGUS LTD *W 58471G128 101 1,008,444 SH   DFND 1 0 1,008,444 0
MICROBOT MED INC COM 59503A204 442 83,333 SH   DFND 1 0 83,333 0
NEURALSTEM INC COM 64127R500 342 204,823 SH   DFND 1 0 204,823 0
NEUROMETRIX INC COM 641255708 299 934,212 SH   DFND 1 0 934,212 0
OBALON THERAPEUTICS INC COM 67424L209 1,330 685,661 SH   DFND 1 0 685,661 0
OCEAN PWR TECHNOLOGIES INC COM 674870506 269 150,000 SH   DFND 1 0 150,000 0
ODONATE THERAPEUTICS INC COM 676079106 2,417 92,854 SH   DFND 1 0 92,854 0
ONCONOVA THERAPEUTICS INC *W 68232V116 13 631,812 SH   DFND 1 0 631,812 0
ONCONOVA THERAPEUTICS INC COM 68232V405 682 802,846 SH   DFND 1 0 802,846 0
ORAGENICS INC COM 684023302 334 618,822 SH   DFND 1 0 618,822 0
ORAMED PHARMACEUTICALS INC COM 68403P903 357 1,120 SH Call DFND 1 0 1,120 0
ORAMED PHARMACEUTICALS INC COM 68403P953 43 135 SH Put DFND 1 0 135 0
ORAMED PHARMACEUTICALS INC COM 68403P203 593 185,800 SH   DFND 1 0 185,800 0
PARETEUM CORP COM 69946T207 2,901 2,248,578 SH   DFND 1 0 2,248,578 0
PAVMED INC *W 70387R122 949 2,964,629 SH   DFND 1 0 2,964,629 0
PHASEBIO PHARMACEUTICALS INC COM 717224109 520 124,788 SH   DFND 1 0 124,788 0
PLURISTEM THERAPEUTICS INC COM 72940R950 67 179 SH Put DFND 1 0 179 0
PLURISTEM THERAPEUTICS INC COM 72940R300 139 37,191 SH   DFND 1 0 37,191 0
PLUS THERAPEUTICS INC COM 72941H400 389 113,600 SH   DFND 1 0 113,600 0
PULMATRIX INC COM 74584P202 866 1,058,682 SH   DFND 1 0 1,058,682 0
REWALK ROBOTICS LTD SHS M8216Q200 352 115,000 SH   DFND 1 0 115,000 0
SEANERGY MARITIME HOLDINGS CORP SHS Y73760301 583 1,210,099 SH   DFND 1 0 1,210,099 0
SEANERGY MARITIME HOLDINGS CORP *W Y73760152 138 917,337 SH   DFND 1 0 917,337 0
SEELOS THERAPEUTICS INC COM 81577F109 451 491,237 SH   DFND 1 0 491,237 0
SENESTECH INC COM COM 81720R109 49 48,294 SH   DFND 1 0 48,294 0
SESEN BIO INC COM 817763955 43 365 SH Put DFND 1 0 365 0
SPDR GOLD TR SHS 78463V907 21,446 2,428 SH Call DFND 1 0 2,428 0
SPDR S&P 500 ETF ETF 78462F903 14,987 505 SH Call DFND 1 0 505 0
SPDR S&P 500 ETF ETF 78462F953 29,618 998 SH Put DFND 1 0 998 0
SPDR S&P BIOTECH ETF 78464A950 3,866 507 SH Put DFND 1 0 507 0
SYNTHETIC BIOLOGICS INC COM 87164U201 379 835,459 SH   DFND 1 0 835,459 0
TITAN MEDICAL INC COM 88830X819 44 41,085 SH   DFND 1 0 41,085 0
TITAN PHARMACEUTICALS INC COM 888314957 3 106 SH Put DFND 1 0 106 0
TITAN PHARMACEUTICALS INC COM 888314507 22 83,218 SH   DFND 1 0 83,218 0
TOP SHIPS INC COM Y8897Y164 572 204,227 SH   DFND 1 0 204,227 0
VASCULAR BIOGENICS LTD COM M96883109 162 119,681 SH   DFND 1 0 119,681 0
VAXART INC COM 92243A200 430 1,197,710 SH   DFND 1 0 1,197,710 0
VBI VACCINES INC COM 91822J103 413 876,157 SH   DFND 1 0 876,157 0
VIKING THERAPEUTICS INC COM 92686J906 138 200 SH Call DFND 1 0 200 0
VISLINK TECHNOLOGIES INC COM 92836Y201 61 115,314 SH   DFND 1 0 115,314 0
XENETIC BIOSCIENCES INC COM 984015503 484 404,550 SH   DFND 1 0 404,550 0
XENETIC BIOSCIENCES INC *W 984015131 258 266,789 SH   DFND 1 0 266,789 0