The Securities and Exchange Commission has not necessarily reviewed the information in this filing and has not determined if it is accurate and complete.
The reader should not assume that the information is accurate and complete.

UNITED STATES SECURITIES AND EXCHANGE COMMISSION
Washington, D.C. 20549
FORM 13F

FORM 13F INFORMATION TABLE
OMB APPROVAL
OMB Number: 3235-0006
Estimated average burden
hours per response: 23.8
COLUMN 1 COLUMN 2 COLUMN 3 COLUMN 4 COLUMN 5 COLUMN 6 COLUMN 7 COLUMN 8
VALUE SHRS OR SH/ PUT/ INVESTMENT OTHER VOTING AUTHORITY
NAME OF ISSUER TITLE OF CLASS CUSIP (x$1000) PRN AMT PRN CALL DISCRETION MANAGER SOLE SHARED NONE
3M CO COM COM 88579Y101 16,974 105,966 SH   DFND   104,916 0 1,050
ABBOTT LABORATORIES COM 002824100 382 3,511 SH   DFND   3,310 0 201
ABBVIE INC COM COM 00287Y109 24,983 285,230 SH   DFND   283,120 0 2,109
ACCENTURE PLC COM g1151c101 15,700 69,471 SH   DFND   69,097 0 374
ACTIVISION BLIZZARD INC COM 00507v109 17,864 220,677 SH   DFND   218,941 0 1,736
AEGLEA BIOTHERAPEUTICS INC COM 00773j103 521 73,500 SH   DFND   73,000 0 500
AFLAC INC COM COM 001055102 1,891 52,010 SH   DFND   51,266 0 744
AGILENT TECH INC COM 00846u101 260 2,575 SH   DFND   2,575 0 0
AKAMAI TECHNOLOGIES, INC COM 00971t101 5,996 54,240 SH   DFND   53,929 0 311
ALPHABET INC CAP STK CL A COM 02079k305 2,664 1,818 SH   DFND   1,818 0 0
ALPHABET INC CAP STK CL C COM 02079k107 28,168 19,167 SH   DFND   19,013 0 154
ALTRIA GROUP INC COM 02209s103 1,181 30,557 SH   DFND   30,557 0 0
AMAZON.COM INC COM 023135106 40,238 12,779 SH   DFND   12,688 0 91
AMER ELEC PWR INC COM COM 025537101 637 7,788 SH   DFND   7,771 0 17
AMERICAN EXPRESS CO COM COM 025816109 1,261 12,575 SH   DFND   12,575 0 0
AMGEN INC COM COM 031162100 742 2,919 SH   DFND   2,919 0 0
APPLE INC COM COM 037833100 62,417 538,960 SH   DFND   534,087 0 4,873
ART ADVANCED RESEARCH TECHNOLO COM 04287x103 0 10,000 SH   DFND   10,000 0 0
AT&T INC. COM 00206r102 8,513 298,588 SH   DFND   294,782 0 3,806
AXION INTERNATIONAL HOLDINGS I COM 05462d101 0 95,714 SH   DFND   95,714 0 0
BANK OF AMERICA CORP COM 060505104 289 12,004 SH   DFND   12,004 0 0
BERKSHIRE HATHAWAY INC DEL CL COM 084670702 13,112 61,575 SH   DFND   61,157 0 418
BIOCRYST PHARMACEUTICALS COM 09058v103 258 75,000 SH   DFND   75,000 0 0
BIOSIGNIA INC COM 090998345 0 130,000 SH   DFND   130,000 0 0
BLACK STONE MINERALS LP COM 09225m101 172 28,000 SH   DFND   28,000 0 0
BLACKROCK INC COM COM 09247X101 27,290 48,425 SH   DFND   48,155 0 270
BLACKSTONE GROUP INC CL A COM 09260d107 313 6,000 SH   DFND   6,000 0 0
BOOKING HOLDINGS INC COM 09857l108 202 118 SH   DFND   118 0 0
BRISTOLMYERS SQUIBB COM 110122108 6,992 115,972 SH   DFND   114,287 0 1,685
CALITHERA BIOSCIENCES, INC. COM 13089p101 388 112,580 SH   DFND   112,580 0 0
CAPITAL ONE FINANCIAL COM 14040h105 299 4,154 SH   DFND   4,154 0 0
CATERPILLAR INC COM 149123101 969 6,500 SH   DFND   6,500 0 0
CHEVRON CORPORATION COM 166764100 767 10,648 SH   DFND   10,598 0 50
CISCO SYS INC COM COM 17275R102 14,284 362,629 SH   DFND   360,731 0 1,898
CLOROX COMPANY COM 189054109 14,769 70,270 SH   DFND   69,811 0 459
CME GROUP INC COM COM 12572Q105 27,049 161,669 SH   DFND   160,312 0 1,357
COCA COLA COMPANY COM 191216100 1,367 27,685 SH   DFND   27,685 0 0
COMCAST CORP NEW CL A COM 20030n101 629 13,605 SH   DFND   13,605 0 0
COMMONWEALTH BANKSHARES INC (D COM 202736104 0 11,761 SH   DFND   11,761 0 0
CONSTELLATION BRANDS INC CL A COM 21036p108 352 1,855 SH   DFND   1,855 0 0
COSTCO WHOLESALE COM 22160k105 743 2,092 SH   DFND   2,092 0 0
CUMMINS INC COM 231021106 1,734 8,210 SH   DFND   8,210 0 0
DANAHER CORP COM COM 235851102 24,090 111,874 SH   DFND   111,058 0 816
DISNEY WALT CO COM 254687106 12,070 97,278 SH   DFND   96,098 0 1,180
DOLLAR GENERAL CORP COM 256677105 12,985 61,947 SH   DFND   61,507 0 440
DOLLAR TREE STORES INC COM 256746108 202 2,208 SH   DFND   2,208 0 0
DOMINION RES INC VA NEW COM 25746u109 8,876 112,460 SH   DFND   111,089 0 1,370
DOW INC COM 260557103 421 8,946 SH   DFND   8,946 0 0
DUKE ENERGY CORPORATION NEW COM 26441c204 1,466 16,559 SH   DFND   16,136 0 423
DUPONT DE NEMOURS INC. COM 26614n102 338 6,085 SH   DFND   6,085 0 0
ECOLAB INC COM COM 278865100 513 2,567 SH   DFND   2,567 0 0
ENBRIDGE INC COM 29250n105 454 15,538 SH   DFND   15,504 0 34
EPIGENOMICS AG BERLIN COM d2552q171 29 10,000 SH   DFND   10,000 0 0
EXXON MOBIL CORP COM COM 30231G102 787 22,914 SH   DFND   22,914 0 0
FACEBOOK COM 30303m102 20,329 77,623 SH   DFND   77,075 0 548
FEDEXCORP COM 31428x106 277 1,103 SH   DFND   1,103 0 0
FIBROGEN INC COM 31572q808 411 10,000 SH   DFND   10,000 0 0
FIVE PRIME THERAPEUTICS, INC. COM 33830x104 235 50,000 SH   DFND   50,000 0 0
GENERAL DYNAMICS CRP COM 369550108 828 5,984 SH   DFND   5,984 0 0
GENERAL MILLS INC COM 370334104 8,097 131,272 SH   DFND   130,648 0 624
GILEAD SCIENCES INC COM COM 375558103 816 12,914 SH   DFND   12,914 0 0
GOLDMAN SACHS GROUP INC COM 38141g104 286 1,425 SH   DFND   1,425 0 0
HOME DEPOT INC COM COM 437076102 9,326 33,580 SH   DFND   33,350 0 230
HONEYWELL INTERNATIONAL INC CO COM 438516106 9,482 57,601 SH   DFND   57,288 0 313
IDEX CORPORATION COM 45167r104 4,401 24,125 SH   DFND   24,125 0 0
IDEXX LABORATORIES COM 45168d104 11,649 29,633 SH   DFND   29,446 0 187
ILLINOIS TOOL WORKS COM 452308109 776 4,017 SH   DFND   4,017 0 0
INTEL CORP COM 458140100 8,771 169,394 SH   DFND   168,150 0 1,244
INTL BUSINESS MACHINES COM 459200101 890 7,314 SH   DFND   6,674 0 640
INTRA CELLULAR THERAPIES INC COM 46116x101 1,355 52,788 SH   DFND   52,588 0 200
ISHARES TR DOW JONES SEL DIVID COM 464287168 1,336 16,385 SH   DFND   16,385 0 0
JOHNSON & JOHNSON COM 478160104 11,860 79,659 SH   DFND   79,090 0 569
JPMORGAN CHASE & CO COM 46625h100 22,019 228,722 SH   DFND   227,548 0 1,175
KIMBERLY CLARK CORP COM 494368103 249 1,689 SH   DFND   1,689 0 0
KINDER MORGAN INC COM 49456b101 631 51,186 SH   DFND   51,186 0 0
KKR & CO INC COM 48251w104 597 17,375 SH   DFND   17,375 0 0
LABORATORY CRP OF AMER HLDGS COM 50540r409 10,049 53,377 SH   DFND   52,939 0 438
LAUDER ESTEE COS INC CL A COM 518439104 13,161 60,302 SH   DFND   59,920 0 382
LINDE PLC COM COM g5494j103 15,457 64,910 SH   DFND   64,572 0 338
LOWE'S COS COM 548661107 204 1,230 SH   DFND   1,230 0 0
LULULEMON ATHLETICA INC COM 550021109 8,603 26,121 SH   DFND   25,969 0 152
MARTIN MARIETTA MATERIALS INC COM 573284106 7,938 33,728 SH   DFND   33,456 0 272
MASCO CORP COM 574599106 273 4,950 SH   DFND   4,950 0 0
MC DONALDS CORP COM 580135101 17,311 78,871 SH   DFND   78,195 0 676
MEDTRONIC, PLC COM g5960l103 6,459 62,157 SH   DFND   61,836 0 321
MERCK & CO INC NEW COM 58933y105 1,181 14,233 SH   DFND   14,233 0 0
MICROSOFT CORP COM 594918104 49,608 235,860 SH   DFND   234,392 0 1,468
MONDELEZ INTL INC COM COM 609207105 11,696 203,584 SH   DFND   202,073 0 1,511
NEKTAR THERAPEUTICS COM 640268108 423 25,500 SH   DFND   25,500 0 0
NESTLES A SPONSORED ADR REPSTG COM 641069406 463 3,880 SH   DFND   3,880 0 0
NEXTERA ENERGY INC COM 65339f101 1,205 4,342 SH   DFND   4,241 0 101
NIKE INC CL B COM 654106103 17,531 139,643 SH   DFND   138,690 0 953
NORFOLK SOUTHERN CORP COM 655844108 2,985 13,950 SH   DFND   13,950 0 0
NORTHROP GRUMMAN CORP COM 666807102 215 680 SH   DFND   680 0 0
NOVELION THERAPEUT F ESC COM 670esc011 0 26,000 SH   DFND   26,000 0 0
NVIDIA CORP COM 67066g104 31,022 57,318 SH   DFND   56,918 0 400
NXP SEMICONDUCTORS NV COM n6596x109 7,383 59,157 SH   DFND   58,921 0 236
ORACLE CORP COM COM 68389X105 2,566 42,978 SH   DFND   42,413 0 565
OWL ROCK CAPITAL CORP COM 69121k104 1,310 108,626 SH   DFND   0 0 108,626
PAYCHEX INC COM 704326107 8,424 105,608 SH   DFND   104,479 0 1,129
PAYPAL HOLDINGS INC COM 70450y103 34,943 177,348 SH   DFND   175,961 0 1,387
PEPSICO INCORPORATED COM 713448108 1,039 7,493 SH   DFND   7,493 0 0
PERRIGO COMPANY COM g97822103 265 5,779 SH   DFND   5,779 0 0
PFIZER INC COM 717081103 7,526 205,077 SH   DFND   201,480 0 3,597
PHILIP MORRIS INTL INC COM 718172109 853 11,379 SH   DFND   11,379 0 0
PROCTER & GAMBLE COM 742718109 8,962 64,477 SH   DFND   62,958 0 1,519
PROQR THERAPEUTICS N.V. COM n71542109 287 60,000 SH   DFND   60,000 0 0
PROTAGONIST THERAPEUTICS INC COM 74366E102 435 22,250 SH   DFND   22,000 0 250
QUALCOMM INC COM COM 747525103 597 5,074 SH   DFND   5,074 0 0
QUEST DIAGNOSTICS INC COM 74834L100 245 2,143 SH   DFND   2,143 0 0
RAYTHEON TECHNOLOGIES CORP COM COM 75513e101 1,224 21,267 SH   DFND   20,997 0 270
ROYAL BANK OF CANADA COM 780087102 1,163 16,578 SH   DFND   16,578 0 0
SABINE ROYALTY TRUST UBI COM 785688102 293 10,081 SH   DFND   10,081 0 0
SALESFORCE.COM INC COM 79466l302 14,563 57,948 SH   DFND   57,604 0 344
SANGAMO BIOSCIENCES INC COM 800677106 121 12,780 SH   DFND   11,880 0 900
SAVI MEDIA GROUP INC (NO VALUE COM 80517r207 0 294,999 SH   DFND   294,999 0 0
SCHWAB (CHARLES) CORP COM 808513105 723 19,945 SH   DFND   19,440 0 505
SCOTTS MIRACLE-GRO CO COM 810186106 373 2,440 SH   DFND   2,440 0 0
SHERWIN WILLIAMS CO COM 824348106 466 669 SH   DFND   669 0 0
SOUTHERN CO COM 842587107 710 13,100 SH   DFND   13,049 0 51
STANDARD & POOR'S DEP RCPTS COM 78462f103 5,164 15,419 SH   DFND   15,419 0 0
STARBUCKS CORP COM 855244109 14,423 167,861 SH   DFND   167,018 0 843
STRYKER CORP COM 863667101 893 4,287 SH   DFND   4,287 0 0
SUPERNUS PHARMACEUTICALS INC COM 868459108 503 24,145 SH   DFND   24,000 0 145
TARGET CORPORATION COM 87612e106 752 4,778 SH   DFND   4,778 0 0
THERMO FISHER CORP COM COM 883556102 14,319 32,430 SH   DFND   32,143 0 287
TRUIST FINANCIAL CORP COM 89832q109 307 8,074 SH   DFND   8,074 0 0
TYME TECHNOLOGIES INC NEW COM 90238j103 39 40,000 SH   DFND   40,000 0 0
UB BANCORP COM COM 903450104 3,488 332,858 SH   DFND   332,858 0 0
UNILEVER PLC-SPONSORED ADR COM 904767704 262 4,245 SH   DFND   4,245 0 0
UNIONPACIFIC CORP COM 907818108 216 1,096 SH   DFND   1,096 0 0
UNITED HEALTHCARE CORP COM 91324p102 894 2,866 SH   DFND   2,866 0 0
UNITED PARCEL SERVICE - CL B COM 911312106 15,026 90,174 SH   DFND   89,282 0 892
V F CORP COM 918204108 7,030 100,072 SH   DFND   99,534 0 538
VERISK ANALYTICS COM 92345y106 9,321 50,299 SH   DFND   50,000 0 299
VERIZON COMMUNICATIONS COM 92343v104 9,152 153,844 SH   DFND   153,234 0 610
VIACOMCBS INC CL B COM 92556h206 5,658 201,983 SH   DFND   201,503 0 480
VIBE RECORDS INC NEW COM (DELI COM 925563108 0 11,000 SH   DFND   11,000 0 0
VISA INC CL A COM 92826c839 209 1,044 SH   DFND   1,044 0 0
WALMART INC. COM 931142103 8,727 62,375 SH   DFND   61,838 0 537
WASTE MANAGEMENT INC DEL COM 94106l109 9,182 81,137 SH   DFND   80,740 0 397
WELLS FARGO & CO NEW COM 949746101 520 22,137 SH   DFND   22,137 0 0
ZOETIS INC COM 98978v103 12,872 77,839 SH   DFND   77,323 0 516
iSHARE MSCI TAIWAN CAPPED ETF ADR 46434g772 449 10,000 SH   DFND   10,000 0 0
AMERIC INT GR WTS EXP 1/19/202 WT acg874152 0 100,444 SH   DFND   100,444 0 0
FOREST LABORATORIES CONTINGENT WT 187cvr907 0 45,000 SH   DFND   45,000 0 0