The Securities and Exchange Commission has not necessarily reviewed the information in this filing and has not determined if it is accurate and complete.
The reader should not assume that the information is accurate and complete.

UNITED STATES SECURITIES AND EXCHANGE COMMISSION
Washington, D.C. 20549
FORM 13F

FORM 13F INFORMATION TABLE
OMB APPROVAL
OMB Number: 3235-0006
Estimated average burden
hours per response: 23.8
COLUMN 1 COLUMN 2 COLUMN 3 COLUMN 4 COLUMN 5 COLUMN 6 COLUMN 7 COLUMN 8
VALUE SHRS OR SH/ PUT/ INVESTMENT OTHER VOTING AUTHORITY
NAME OF ISSUER TITLE OF CLASS CUSIP FIGI (to the nearest dollar) PRN AMT PRN CALL DISCRETION MANAGER SOLE SHARED NONE
ACHIEVE LIFE SCIENCES INC COM 004468500   156,984 33,119 SH   DFND 1,2 0 33,119 0
ADVERUM BIOTECHNOLOGIES INC COM NEW 00773U207   2,164,764 308,371 SH   DFND 1,2 0 308,371 0
AG MTG INVT TR INC COM NEW 001228501   1,000,865 133,271 SH   DFND 1,2 0 133,271 0
ANGI INC COM CL A NEW 00183L102   13,919,358 5,395,100 SH   DFND 1,2 0 5,395,100 0
AQUESTIVE THERAPEUTICS INC COM 03843E104   119,520 24,000 SH   DFND 1,2 0 24,000 0
AT&T INC COM 00206R102   211,278,276 9,603,558 SH   DFND 1,2 0 9,603,558 0
ATAI LIFE SCIENCES NV SHS N0731H103   43,365 37,384 SH   DFND 1,2 0 37,384 0
B2GOLD CORP COM 11777Q209   52,933,123 17,186,079 SH   DFND 1,2 0 17,186,079 0
BIOHAVEN LTD COM G1110E107   274,635 5,496 SH   DFND 1,2 0 5,496 0
BLACK DIAMOND THERAPEUTICS I COM 09203E105   230,485 52,985 SH   DFND 1,2 0 52,985 0
BROADWIND INC COM NEW 11161T207   49,999 22,026 SH   DFND 1,2 0 22,026 0
CARIBOU BIOSCIENCES INC COM 142038108   1,440,412 734,904 SH   DFND 1,2 0 734,904 0
CELCUITY INC COM 15102K100   260,299 17,458 SH   DFND 1,2 0 17,458 0
CELLECTAR BIOSCIENCES INC COM NEW 15117F807   53,564 25,030 SH   DFND 1,2 0 25,030 0
CENTERRA GOLD INC COM 152006102   15,869,496 2,216,410 SH   DFND 1,2 0 2,216,410 0
CHIMERA INVT CORP COM SHS 16934Q802   5,373,858 339,473 SH   DFND 1,2 0 339,473 0
CHIMERIX INC COM 16934W106   237,116 254,963 SH   DFND 1,2 0 254,963 0
COMPASS THERAPEUTICS INC COM 20454B104   56,133 30,507 SH   DFND 1,2 0 30,507 0
CREATIVE MEDIA & CMNTY TR COM NEW 125525584   239,055 486,378 SH   DFND 1,2 0 486,378 0
DESPEGAR COM CORP ORD SHS G27358103   1,239,231 99,938 SH   DFND 1,2 0 99,938 0
DISC MEDICINE INC COM 254604101   324,766 6,609 SH   DFND 1,2 0 6,609 0
DIVERSIFIED HEALTHCARE TR COM SH BEN INT 25525P107   1,853,229 442,298 SH   DFND 1,2 0 442,298 0
DOLE PLC ORD SHS G27907107   106,658,498 6,547,483 SH   DFND 1,2 0 6,547,483 0
EDGEWISE THERAPEUTICS INC COM 28036F105   205,139 7,686 SH   DFND 1,2 0 7,686 0
GROUPON INC COM NEW 399473206   99,570,865 10,181,070 SH   DFND 1,2 0 10,181,070 0
I-80 GOLD CORP COM 44955L106   11,471,900 9,889,569 SH   DFND 1,2 0 9,889,569 0
IMMATICS N.V SHS N44445109   279,111 24,462 SH   DFND 1,2 0 24,462 0
INOZYME PHARMA INC COM 45790W108   986,049 188,537 SH   DFND 1,2 0 188,537 0
INTERNATIONAL SEAWAYS INC COM Y41053102   38,897,637 754,415 SH   DFND 1,2 0 754,415 0
IOVANCE BIOTHERAPEUTICS INC COM 462260100   350,951 37,375 SH   DFND 1,2 0 37,375 0
LARIMAR THERAPEUTICS INC COM 517125100   211,624 32,309 SH   DFND 1,2 0 32,309 0
MINERALYS THERAPEUTICS INC COM 603170101   1,657,823 136,897 SH   DFND 1,2 0 136,897 0
NAVIOS MARITIME PARTNERS L P COM UNIT LPI Y62267409   10,661,254 170,226 SH   DFND 1,2 0 170,226 0
NEW PAC METALS CORP COM 64782A107   49,960 33,530 SH   DFND 1,2 0 33,530 0
NEW YORK MTG TR INC COM 649604840   1,316,456 207,971 SH   DFND 1,2 0 207,971 0
OCULAR THERAPEUTIX INC COM 67576A100   3,812,340 438,200 SH   DFND 1,2 0 438,200 0
ORANGE SPONSORED ADR 684060106   2,882,915 251,125 SH   DFND 1,2 0 251,125 0
OSISKO DEVELOPMENT CORP COM NEW 68828E809   51,740 24,291 SH   DFND 1,2 0 24,291 0
PIONEER PWR SOLUTIONS INC COM NEW 723836300   49,245 10,500 SH   DFND 1,2 0 10,500 0
PRAXIS PRECISION MEDICINES I COM NEW 74006W207   3,871,521 67,284 SH   DFND 1,2 0 67,284 0
RAPT THERAPEUTICS INC COM 75382E109   1,026,555 510,724 SH   DFND 1,2 0 510,724 0
RENEW ENERGY GLOBAL PLC CL A SHS G7500M104   372,928 59,289 SH   DFND 1,2 0 59,289 0
REZOLUTE INC COM NEW 76200L309   117,802 24,289 SH   DFND 1,2 0 24,289 0
SCORPIO TANKERS INC SHS Y7542C130   3,230,603 45,310 SH   DFND 1,2 0 45,310 0
SHELL PLC SPON ADS 780259305   2,699,004 40,925 SH   DFND 1,2 0 40,925 0
SHUTTERSTOCK INC COM 825690100   3,388,800 95,810 SH   DFND 1,2 0 95,810 0
SYROS PHARMACEUTICALS INC COM NEW 87184Q206   105,804 49,211 SH   DFND 1,2 0 49,211 0
TELADOC HEALTH INC COM 87918A105   18,794,425 2,047,323 SH   DFND 1,2 0 2,047,323 0
TSAKOS ENERGY NAVIGATION LTD SHS G9108L173   12,660,390 504,398 SH   DFND 1,2 0 504,398 0
TSCAN THERAPEUTICS INC COM 89854M101   217,741 43,723 SH   DFND 1,2 0 43,723 0
UNIQURE NV SHS N90064101   1,658,787 336,468 SH   DFND 1,2 0 336,468 0
VAXART INC COM NEW 92243A200   43,323 51,028 SH   DFND 1,2 0 51,028 0
VERVE THERAPEUTICS INC COM 92539P101   220,704 45,600 SH   DFND 1,2 0 45,600 0
X4 PHARMACEUTICALS INC COM 98420X103   1,072,749 1,602,792 SH   DFND 1,2 0 1,602,792 0