Institutional shares held 27 Million
42.2K calls
9.3K puts
Total value of holdings $902M
$1.41M calls
$311K puts
Market Cap $880M
26,297,000 Shares Out.
Institutional ownership 102.58%
# of Institutions 185


Latest Institutional Activity in CSTL

Top Purchases

Q4 2025
Sg Americas Securities, LLC Shares Held: 21.3K ($711K)
Q4 2025
Portside Wealth Group, LLC Shares Held: 5.94K ($199K)
Q4 2025
Allspring Global Investments Holdings, LLC Shares Held: 159K ($5.32M)
Q4 2025
Farther Finance Advisors, LLC Shares Held: 3.34K ($112K)
Q4 2025
Green Alpha Advisors, LLC Shares Held: 10.2K ($342K)

Top Sells

Q4 2025
First Bank & Trust Shares Held: 16.7K ($559K)
Q4 2025
Assetmark, Inc Shares Held: 5.29K ($177K)
Q4 2025
Nisa Investment Advisors, LLC Shares Held: 281 ($9.4K)
Q3 2025
Citadel Advisors LLC Shares Held: 251K ($8.39M)
Q3 2025
Wasatch Advisors Inc Shares Held: 669K ($22.4M)

About CSTL

Castle Biosciences, Inc., a commercial-stage diagnostics company, focuses to provide diagnostic and prognostic testing services for dermatological cancers. Its lead product is DecisionDx-Melanoma, a multi-gene expression profile (GEP) test to identify the risk of metastasis for patients diagnosed with invasive cutaneous melanoma. The company also offers DecisionDx-UM test, a proprietary GEP test that predicts the risk of metastasis for patients with uveal melanoma, a rare eye cancer; DecisionDx-SCC, a proprietary 40-gene expression profile test that uses an individual patient's tumor biology to predict individual risk of squamous cell carcinoma metastasis for patients with one or more risk factors; and DecisionDx DiffDx-Melanoma and myPath Melanoma, a proprietary GEP test to diagnose suspicious pigmented lesions. It offers test services through physicians and their patients. The company was founded in 2007 and is headquartered in Friendswood, Texas.


Insider Transactions at CSTL

Insider Transaction List

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Date Insider Transaction Ownership Type Shares Traded Value / Price
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Last 12 Months Summary

Buy / Acquisition
442K Shares
From 15 Insiders
Exercise of conversion of derivative security 354K shares
Grant, award, or other acquisition 88.8K shares
Sell / Disposition
411K Shares
From 9 Insiders
Open market or private sale 309K shares
Payment of exercise price or tax liability 102K shares

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