The Securities and Exchange Commission has not necessarily reviewed the information in this filing and has not determined if it is accurate and complete. | |||||||||||||||||
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UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 13F FORM 13F INFORMATION TABLE |
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| COLUMN 1 | COLUMN 2 | COLUMN 3 | COLUMN 4 | COLUMN 5 | COLUMN 6 | COLUMN 7 | COLUMN 8 | |||||
| VALUE | SHRS OR | SH/ | PUT/ | INVESTMENT | OTHER | VOTING AUTHORITY | ||||||
| NAME OF ISSUER | TITLE OF CLASS | CUSIP | FIGI | (to the nearest dollar) | PRN AMT | PRN | CALL | DISCRETION | MANAGER | SOLE | SHARED | NONE |
| ACELYRIN Inc | COM | 00445A100 | 8,527,248 | 1,729,665 | SH | DFND | 2 | 1,729,665 | 0 | 0 | ||
| Achilles Therapeutics PLC | SPONSORED ADS | 00449L102 | 770,483 | 755,375 | SH | DFND | 2 | 755,375 | 0 | 0 | ||
| ADC Therapeutics SA | SHS | H0036K147 | 3,664,902 | 1,163,461 | SH | DFND | 2 | 1,163,461 | 0 | 0 | ||
| Adobe Inc | COM | 00724F101 | 517,780 | 1,000 | SH | DFND | 2 | 1,000 | 0 | 0 | ||
| Agenus Inc | COM NEW | 00847G804 | 4,247,000 | 775,000 | SH | DFND | 2 | 775,000 | 0 | 0 | ||
| Allovir Inc | COM | 019818103 | 5,333,810 | 6,597,167 | SH | DFND | 2 | 6,597,167 | 0 | 0 | ||
| Alphabet Inc | CAP STK CL A | 02079K305 | 1,824,130 | 11,000 | SH | DFND | 2 | 11,000 | 0 | 0 | ||
| Alto Neuroscience Inc | COM SHS | 02157Q109 | 4,477,685 | 391,406 | SH | DFND | 2 | 391,406 | 0 | 0 | ||
| Amazon.com Inc | COM | 023135106 | 6,474,968 | 34,750 | SH | DFND | 2 | 34,750 | 0 | 0 | ||
| Apellis Pharmaceuticals Inc | COM | 03753U106 | 62,502,740 | 2,167,224 | SH | DFND | 2 | 2,167,224 | 0 | 0 | ||
| Applied Therapeutics Inc | COM | 03828A101 | 13,887,028 | 1,633,768 | SH | DFND | 2 | 1,633,768 | 0 | 0 | ||
| Arcus Biosciences Inc | COM | 03969F109 | 24,648,657 | 1,612,077 | SH | DFND | 1 | 1,612,077 | 0 | 0 | ||
| Argenx SE | SPONSORED ADR | 04016X101 | 77,868,166 | 143,647 | SH | DFND | 2 | 143,647 | 0 | 0 | ||
| Arrowhead Pharmaceuticals Inc | COM | 04280A100 | 47,626,530 | 2,458,778 | SH | DFND | 2 | 2,458,778 | 0 | 0 | ||
| Ascendis Pharma A/S | SPONSORED ADR | 04351P101 | 51,948,085 | 347,921 | SH | DFND | 2 | 347,921 | 0 | 0 | ||
| Avidity Biosciences Inc | COM | 05370A108 | 66,173,004 | 1,440,736 | SH | DFND | 2 | 1,440,736 | 0 | 0 | ||
| Beigene Ltd | SPONSORED ADR | 07725L102 | 126,469,626 | 563,314 | SH | DFND | 2 | 563,314 | 0 | 0 | ||
| Bicara Therapeutics Inc | COM | 055477103 | 78,264,904 | 3,072,827 | SH | DFND | 2 | 3,072,827 | 0 | 0 | ||
| BIOAGE Labs Inc | COM | 09077V100 | 6,240,000 | 300,000 | SH | DFND | 2 | 300,000 | 0 | 0 | ||
| Biohaven Ltd | COM | G1110E107 | 14,168,494 | 283,540 | SH | DFND | 2 | 283,540 | 0 | 0 | ||
| Black Diamond Therapeutics Inc | COM | 09203E105 | 4,552,349 | 1,046,517 | SH | DFND | 2 | 1,046,517 | 0 | 0 | ||
| Caribou Biosciences Inc | COM | 142038108 | 206,480 | 105,347 | SH | DFND | 2 | 105,347 | 0 | 0 | ||
| Cartesian Therapeutics Inc | COM NEW | 816212302 | 9,224,444 | 572,236 | SH | DFND | 2 | 572,236 | 0 | 0 | ||
| Centessa Pharmaceuticals PLC | SPONSORED ADS | 152309100 | 52,106,245 | 3,258,677 | SH | DFND | 2 | 3,258,677 | 0 | 0 | ||
| Crinetics Pharmaceuticals Inc | COM | 22663K107 | 66,923,217 | 1,309,652 | SH | DFND | 2 | 1,309,652 | 0 | 0 | ||
| CrowdStrike Holdings Inc | CL A | 22788C105 | 7,011,750 | 25,000 | SH | DFND | 2 | 25,000 | 0 | 0 | ||
| Cullinan Therapeutics Inc | COM | 230031106 | 20,278,116 | 1,211,357 | SH | DFND | 2 | 1,211,357 | 0 | 0 | ||
| Cyclerion Therapeutics Inc | COM | 23255M204 | 300,841 | 116,155 | SH | DFND | 2 | 116,155 | 0 | 0 | ||
| Cytokinetics Inc | COM NEW | 23282W605 | 27,771,269 | 525,971 | SH | DFND | 2 | 525,971 | 0 | 0 | ||
| Datadog Inc | CL A COM | 23804L103 | 3,788,351 | 32,925 | SH | DFND | 2 | 32,925 | 0 | 0 | ||
| Denali Therapeutics Inc | COM | 24823R105 | 24,295,236 | 834,028 | SH | DFND | 2 | 834,028 | 0 | 0 | ||
| Dollar Tree Inc | COM | 256746108 | 703,200 | 10,000 | SH | DFND | 2 | 10,000 | 0 | 0 | ||
| Dynatrace Inc | COM NEW | 268150109 | 4,423,520 | 82,729 | SH | DFND | 2 | 82,729 | 0 | 0 | ||
| Dyne Therapeutics Inc | COM | 26818M108 | 40,757,131 | 1,134,664 | SH | DFND | 2 | 1,134,664 | 0 | 0 | ||
| Edgewise Therapeutics Inc | COM | 28036F105 | 10,785,776 | 404,113 | SH | DFND | 2 | 404,113 | 0 | 0 | ||
| Elastic NV | ORD SHS | N14506104 | 997,880 | 13,000 | SH | DFND | 2 | 13,000 | 0 | 0 | ||
| Erasca Inc | COM | 29479A108 | 24,180,099 | 8,857,179 | SH | DFND | 2 | 8,857,179 | 0 | 0 | ||
| Foghorn Therapeutics Inc. | COM | 344174107 | 6,709,903 | 720,720 | SH | DFND | 2 | 720,720 | 0 | 0 | ||
| Generation Bio Co | COM | 37148K100 | 7,367,351 | 2,982,733 | SH | DFND | 2 | 2,982,733 | 0 | 0 | ||
| GlycoMimetics Inc | COM | 38000Q102 | 332,104 | 1,965,114 | SH | DFND | 2 | 1,965,114 | 0 | 0 | ||
| Gossamer Bio Inc | COM | 38341P102 | 204,185 | 207,000 | SH | Call | DFND | 2 | 207,000 | 0 | 0 | |
| Gossamer Bio Inc | COM | 38341P102 | 13,100,980 | 13,281,610 | SH | DFND | 2 | 13,281,610 | 0 | 0 | ||
| Gritstone bio Inc | COM | 39868T105 | 1,924,162 | 3,318,093 | SH | DFND | 2 | 3,318,093 | 0 | 0 | ||
| HOOKIPA Pharma Inc | COM NEW | 43906K209 | 2,436,552 | 566,640 | SH | DFND | 2 | 566,640 | 0 | 0 | ||
| IGM Biosciences Inc | COM | 449585108 | 55,085,180 | 3,330,422 | SH | DFND | 2 | 5,017,922 | 0 | 0 | ||
| IHS Holding Limited | ORD SHS | G4701H109 | 7,048,985 | 2,357,520 | SH | DFND | 1 | 2,357,520 | 0 | 0 | ||
| Instil Bio Inc | COM NEW | 45783C200 | 12,954,590 | 192,433 | SH | DFND | 2 | 192,433 | 0 | 0 | ||
| Intel Corp | COM | 458140100 | 938,400 | 40,000 | SH | DFND | 2 | 40,000 | 0 | 0 | ||
| Ionis Pharmaceuticals Inc | COM | 462222100 | 10,015,000 | 250,000 | SH | DFND | 2 | 250,000 | 0 | 0 | ||
| IONQ Inc | COM | 46222L108 | 4,370,000 | 500,000 | SH | DFND | 1 | 500,000 | 0 | 0 | ||
| Iovance Biotherapeutics Inc | COM | 462260100 | 10,385,716 | 1,106,040 | SH | DFND | 2 | 1,106,040 | 0 | 0 | ||
| Ironwood Pharmaceuticals Inc | COM CL A | 46333X108 | 455,392 | 110,532 | SH | DFND | 2 | 110,532 | 0 | 0 | ||
| Jfrog Ltd | ORD SHS | M6191J100 | 1,771,440 | 61,000 | SH | DFND | 2 | 61,000 | 0 | 0 | ||
| Kanzhun Ltd | SPONSORED ADS | 48553T106 | 434,000 | 25,000 | SH | DFND | 2 | 25,000 | 0 | 0 | ||
| Ke Holdings Inc | SPONSORED ADS | 482497104 | 1,991,000 | 100,000 | SH | DFND | 2 | 100,000 | 0 | 0 | ||
| Korro Bio Inc | COM | 500946108 | 13,997,399 | 418,833 | SH | DFND | 2 | 418,833 | 0 | 0 | ||
| Kronos Bio Inc | COM | 50107A104 | 842,870 | 842,954 | SH | DFND | 2 | 842,954 | 0 | 0 | ||
| Kura Oncology Inc | COM | 50127T109 | 26,182,467 | 1,339,942 | SH | DFND | 2 | 1,339,942 | 0 | 0 | ||
| Kymera Therapeutics Inc | COM | 501575104 | 140,557,463 | 2,969,733 | SH | DFND | 2 | 2,969,733 | 0 | 0 | ||
| Lexeo Therapeutics Inc | COM | 52886X107 | 5,455,052 | 603,435 | SH | DFND | 2 | 603,435 | 0 | 0 | ||
| Lexicon Pharmaceuticals Inc | COM NEW | 528872302 | 61,102,678 | 38,918,903 | SH | DFND | 2 | 38,918,903 | 0 | 0 | ||
| Longboard Pharmaceuticals Inc | COM | 54300N103 | 30,104,556 | 903,227 | SH | DFND | 2 | 903,227 | 0 | 0 | ||
| Merus NV | COM | N5749R100 | 34,082,762 | 682,201 | SH | DFND | 2 | 682,201 | 0 | 0 | ||
| Meta Platforms Inc | CL A | 30303M102 | 858,660 | 1,500 | SH | DFND | 2 | 1,500 | 0 | 0 | ||
| Microsoft Corp | COM | 594918104 | 9,462,640 | 22,000 | SH | DFND | 2 | 22,000 | 0 | 0 | ||
| Natera Inc | COM | 632307104 | 1,598,808 | 12,594 | SH | DFND | 2 | 12,594 | 0 | 0 | ||
| Neumora Therapeutics Inc | COM | 640979100 | 34,432,803 | 2,606,571 | SH | DFND | 2 | 2,606,571 | 0 | 0 | ||
| Neurogene Inc | COM | 64135M105 | 7,380,680 | 175,898 | SH | DFND | 2 | 175,898 | 0 | 0 | ||
| New Oriental Education & Technology Group Inc | SPON ADR | 647581206 | 2,919,840 | 38,500 | SH | DFND | 2 | 38,500 | 0 | 0 | ||
| NewAmsterdam Pharma Company NV | ORDINARY SHARES | N62509109 | 15,281,362 | 920,564 | SH | DFND | 2 | 920,564 | 0 | 0 | ||
| Novocure Ltd | ORD SHS | G6674U108 | 5,484,317 | 350,884 | SH | DFND | 1 | 350,884 | 0 | 0 | ||
| Nu Holdings Ltd | ORD SHS CL A | G6683N103 | 682,500 | 50,000 | SH | DFND | 2 | 50,000 | 0 | 0 | ||
| NVIDIA Corp | COM | 67066G104 | 5,942,038 | 48,932 | SH | DFND | 2 | 48,932 | 0 | 0 | ||
| Occidental Petroleum Corp | COM | 674599105 | 1,803,900 | 35,000 | SH | DFND | 2 | 35,000 | 0 | 0 | ||
| Omega Therapeutics Inc | COMMON STOCK | 68217N105 | 1,614,707 | 1,323,530 | SH | DFND | 2 | 1,323,530 | 0 | 0 | ||
| Oric Pharmaceuticals Inc | COM | 68622P109 | 10,327,644 | 1,007,575 | SH | DFND | 1 | 1,007,575 | 0 | 0 | ||
| Ovid Therapeutics Inc | COM | 690469101 | 3,363,000 | 2,850,000 | SH | DFND | 2 | 2,850,000 | 0 | 0 | ||
| Palo Alto Networks Inc | COM | 697435105 | 1,538,100 | 4,500 | SH | DFND | 2 | 4,500 | 0 | 0 | ||
| PayPal Holdings Inc | COM | 70450Y103 | 2,028,780 | 26,000 | SH | Call | DFND | 2 | 26,000 | 0 | 0 | |
| PayPal Holdings Inc | COM | 70450Y103 | 1,170,450 | 15,000 | SH | DFND | 2 | 15,000 | 0 | 0 | ||
| PDD Holdings Inc | SPONSORED ADS | 722304102 | 5,446,459 | 40,401 | SH | DFND | 2 | 40,401 | 0 | 0 | ||
| Perception Capital Corp III | *W EXP 99/99/999 | G7185D114 | 3,800 | 126,666 | SH | Call | DFND | 2 | 126,666 | 0 | 0 | |
| Phathom Pharmaceuticals Inc | COM | 71722W107 | 8,330,414 | 460,753 | SH | DFND | 2 | 460,753 | 0 | 0 | ||
| Procore Technologies Inc | COM | 74275K108 | 1,993,556 | 32,300 | SH | DFND | 2 | 32,300 | 0 | 0 | ||
| Prothena Corporation PLC | SHS | G72800108 | 18,400,323 | 1,099,840 | SH | DFND | 2 | 1,099,840 | 0 | 0 | ||
| Qualcomm Inc | COM | 747525103 | 2,550,750 | 15,000 | SH | DFND | 2 | 15,000 | 0 | 0 | ||
| Rapport Therapeutics Inc | COM | 75383L102 | 7,868,355 | 384,197 | SH | DFND | 2 | 384,197 | 0 | 0 | ||
| Regenxbio Inc | COM | 75901B107 | 2,979,160 | 284,000 | SH | DFND | 2 | 284,000 | 0 | 0 | ||
| Remitly Global Inc | COM | 75960P104 | 334,750 | 25,000 | SH | DFND | 2 | 25,000 | 0 | 0 | ||
| Revolution Medicines Inc | COM | 76155X100 | 34,175,805 | 753,601 | SH | DFND | 2 | 753,601 | 0 | 0 | ||
| Rubrik Inc | CL A | 781154109 | 803,750 | 25,000 | SH | DFND | 2 | 25,000 | 0 | 0 | ||
| Sagimet Biosciences Inc | COM SER A | 786700104 | 2,007,616 | 724,771 | SH | DFND | 2 | 724,771 | 0 | 0 | ||
| Scholar Rock Holding Corp | COM | 80706P103 | 90,188,098 | 11,259,438 | SH | DFND | 2 | 11,259,438 | 0 | 0 | ||
| Sea Ltd | SPONSORED ADS | 81141R100 | 3,535,500 | 37,500 | SH | DFND | 2 | 37,500 | 0 | 0 | ||
| Seer Inc | COM CL A | 81578P106 | 7,880,000 | 4,000,000 | SH | DFND | 2 | 4,000,000 | 0 | 0 | ||
| ServiceNow Inc | COM | 81762P102 | 6,707,925 | 7,500 | SH | DFND | 2 | 7,500 | 0 | 0 | ||
| Silence Therapeutics PLC | ADS | 82686Q101 | 51,481,579 | 2,831,770 | SH | DFND | 2 | 2,831,770 | 0 | 0 | ||
| Solid Biosciences Inc | COM NEW | 83422E204 | 19,160,816 | 2,749,041 | SH | DFND | 2 | 2,749,041 | 0 | 0 | ||
| SpringWorks Therapeutics Inc | COM | 85205L107 | 44,141,540 | 1,377,701 | SH | DFND | 2 | 1,377,701 | 0 | 0 | ||
| Syros Pharmaceuticals Inc | COM NEW | 87184Q206 | 5,562,850 | 2,587,372 | SH | DFND | 2 | 2,587,372 | 0 | 0 | ||
| Taboola.com Ltd | ORD SHS | M8744T106 | 33,497,503 | 9,969,495 | SH | DFND | 1 | 9,969,495 | 0 | 0 | ||
| Taiwan Semiconductor Manufacturing Co Ltd | SPONSORED ADS | 874039100 | 4,341,750 | 25,000 | SH | DFND | 2 | 25,000 | 0 | 0 | ||
| Tango Therapeutics Inc | COM | 87583X109 | 20,050,007 | 2,603,897 | SH | DFND | 2 | 2,603,897 | 0 | 0 | ||
| Taysha Gene Therapies Inc | COM SHS | 877619106 | 9,808,549 | 4,879,875 | SH | DFND | 2 | 4,879,875 | 0 | 0 | ||
| Terns Pharmaceuticals Inc | COM | 880881107 | 834,000 | 100,000 | SH | DFND | 2 | 100,000 | 0 | 0 | ||
| Tourmaline Bio Inc | COM | 89157D105 | 2,350,562 | 91,426 | SH | DFND | 2 | 91,426 | 0 | 0 | ||
| Vaxcyte Inc | COM | 92243G108 | 34,279,972 | 299,991 | SH | DFND | 2 | 299,991 | 0 | 0 | ||
| Vera Therapeutics Inc | CL A | 92337R101 | 37,036,418 | 837,928 | SH | DFND | 2 | 837,928 | 0 | 0 | ||
| Vigil Neuroscience Inc | COM | 92673K108 | 6,769,529 | 1,991,038 | SH | DFND | 2 | 1,991,038 | 0 | 0 | ||
| Visa Inc | COM CL A | 92826C839 | 1,924,650 | 7,000 | SH | DFND | 2 | 7,000 | 0 | 0 | ||
| WAVE Life Sciences Ltd | SHS | Y95308105 | 46,913,610 | 5,721,172 | SH | DFND | 2 | 5,721,172 | 0 | 0 | ||
| Xenon Pharmaceuticals Inc | COM | 98420N105 | 29,282,186 | 743,769 | SH | DFND | 2 | 743,769 | 0 | 0 | ||