Institutional shares held 486 Million
498K calls
150K puts
Total value of holdings $48.3B
$49.5M calls
$14.9M puts
Market Cap $5.54B
55,720,000 Shares Out.
Institutional ownership 871.71%
# of Institutions 282


Latest Institutional Activity in RYTM

Top Purchases

Q3 2025
Perceptive Advisors LLC Shares Held: 419M ($41.7B)
Q3 2025
Vanguard Group Inc Shares Held: 5M ($497M)
Q3 2025
Jpmorgan Chase & CO Shares Held: 1.19M ($118M)
Q3 2025
Alliancebernstein L.P. Shares Held: 980K ($97.4M)
Q3 2025
Capital Research Global Investors Shares Held: 598K ($59.5M)

Top Sells

Q3 2025
Primecap Management CO Shares Held: 4.26M ($424M)
Q3 2025
Sofinnova Investments, Inc. Shares Held: 247K ($24.6M)
Q3 2025
Hood River Capital Management LLC Shares Held: 236K ($23.4M)
Q3 2025
Checkpoint Capital L.P. Shares Held: 764K ($75.9M)
Q3 2025
Westfield Capital Management CO LP Shares Held: 1.07M ($106M)

About RYTM

Rhythm Pharmaceuticals, Inc., a commercial-stage biopharmaceutical company, focuses on the development and commercialization of therapeutics for the treatment of rare genetic diseases of obesity. The company's lead product candidate is IMCIVREE, a potent melanocortin-4 receptor for the treatment of pro-opiomelanocortin (POMC), proprotein convertase subtilisin/kexin type 1, leptin receptor (LEPR) deficiency obesity, and Bardet-Biedl and Alström syndrome. It is also developing setmelanotide, which is in Phase II clinical trials for treating POMC or LEPR heterozygous deficiency obesities, steroid receptor coactivator 1 deficiency obesity, SH2B1 deficiency obesity, MC4 receptor deficiency obesity, Smith-Magenis syndrome obesity, POMC epigenetic disorders, and other MC4R disorders. Rhythm Pharmaceuticals, Inc. has a collaborative research agreement with the Clinical Registry Investigating Bardet-Biedl Syndrome. The company was formerly known as Rhythm Metabolic, Inc. and changed its name to Rhythm Pharmaceuticals, Inc. in October 2015. Rhythm Pharmaceuticals, Inc. was founded in 2008 and is headquartered in Boston, Massachusetts.


Insider Transactions at RYTM

Insider Transaction List

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Date Insider Transaction Ownership Type Shares Traded Value / Price
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Last 12 Months Summary

Buy / Acquisition
586K Shares
From 15 Insiders
Exercise of conversion of derivative security 586K shares
Sell / Disposition
491K Shares
From 9 Insiders
Open market or private sale 491K shares

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