Samir M. Gharib Spruce Biosciences, Inc. (SPRB) insider trading activity

Samir M. Gharib is PRESIDENT AND CFO of SPRUCE BIOSCIENCES, INC.. Currently has a direct ownership of 8,263 shares of SPRB, which is worth approximately $878,687. The most recent transaction as insider was on Dec 15, 2025, when has been sold 362 shares (Common Stock) at a price of $80.67 per share, resulting in proceeds of $29,202. This information was disclosed in a Form 4 filing with the Securities and Exchange Commission (SEC).

Shares Held (Direct Ownership) 8.26K

97.64% 3M change

97.64% 12M change

Total Value Held $878,687

Samir M. Gharib Transaction History

Date	Transaction	Value	Shares Traded	Shares Held
Dec 15 2025	SELL Payment of exercise price or tax liability	$29,202 $80.67 p/Share	362 Reduced 4.2%	8,263 Common Stock
Dec 15 2025	BUY Exercise of conversion of derivative security	-	1,009 Added 10.67%	8,447 Common Stock
Dec 11 2025	SELL Payment of exercise price or tax liability	$60,118 $88.41 p/Share	680 Reduced 8.2%	7,616 Common Stock
Dec 11 2025	BUY Exercise of conversion of derivative security	-	1,900 Added 18.63%	8,296 Common Stock
Dec 10 2025	SELL Payment of exercise price or tax liability	$15,763 $85.67 p/Share	184 Reduced 2.8%	6,396 Common Stock
Dec 10 2025	BUY Exercise of conversion of derivative security	-	514 Added 7.25%	6,580 Common Stock
Oct 20 2025	SELL Payment of exercise price or tax liability	$97,933 $148.16 p/Share	661 Reduced 9.83%	6,066 Common Stock

Oct 20 2025	BUY Exercise of conversion of derivative security	-	2,053 Added 23.38%	6,727 Common Stock
Dec 16 2024	SELL Payment of exercise price or tax liability	$10,540 $0.39 p/Share	27,028 Reduced 7.16%	350,550 Common Stock
Dec 16 2024	BUY Exercise of conversion of derivative security	-	75,750 Added 17.23%	363,841 Common Stock
Dec 10 2024	SELL Payment of exercise price or tax liability	$29,671 $0.54 p/Share	54,948 Reduced 15.4%	301,828 Common Stock
Dec 10 2024	BUY Exercise of conversion of derivative security	-	154,000 Added 30.15%	356,776 Common Stock
Dec 29 2023	BUY Grant, award, or other acquisition	$11,029 $0.98 p/Share	11,255 Added 5.26%	202,776 Common Stock
Dec 15 2023	SELL Payment of exercise price or tax liability	$59,917 $1.66 p/Share	36,095 Reduced 15.86%	191,521 Common Stock
Dec 15 2023	BUY Exercise of conversion of derivative security	-	112,250 Added 35.45%	204,403 Common Stock
Jun 30 2023	SELL Payment of exercise price or tax liability	$55,762 $2.15 p/Share	25,936 Reduced 18.36%	115,366 Common Stock
Jun 30 2023	BUY Grant, award, or other acquisition	$10,274 $0.98 p/Share	10,484 Added 13.65%	66,302 Common Stock
Jun 30 2023	BUY Exercise of conversion of derivative security	-	75,000 Added 34.67%	141,302 Common Stock
Jan 03 2023	SELL Payment of exercise price or tax liability	$17,586 $1.15 p/Share	15,293 Reduced 21.51%	55,818 Common Stock
Jan 03 2023	BUY Exercise of conversion of derivative security	-	37,500 Added 34.53%	71,111 Common Stock
Dec 30 2022	BUY Grant, award, or other acquisition	$0 $0.93 p/Share	1 Added 0.0%	33,611 Common Stock
Jun 30 2022	SELL Payment of exercise price or tax liability	$22,564 $1.74 p/Share	12,968 Reduced 27.84%	33,610 Common Stock
Jun 30 2022	BUY Grant, award, or other acquisition	$8,060 $1.48 p/Share	5,446 Added 10.47%	46,578 Common Stock
Jun 30 2022	BUY Exercise of conversion of derivative security	-	37,500 Added 47.69%	41,132 Common Stock
Dec 31 2021	BUY Other acquisition or disposition	$8,414 $3.79 p/Share	2,220 Added 32.4%	4,632 Common Stock

SMG

Samir M. Gharib

PRESIDENT AND CFO

Daly City, CA

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