Esther Rajavelu Spero Therapeutics, Inc. (SPRO) insider trading activity

Esther Rajavelu is of Spero Therapeutics, Inc.. Currently has a direct ownership of 869,450 shares of SPRO, which is worth approximately $2.1 Million. The most recent transaction as insider was on Nov 07, 2025, when has been sold 40,270 shares (Common Stock) at a price of $2.37 per share, resulting in proceeds of $95,439. This information was disclosed in a Form 4 filing with the Securities and Exchange Commission (SEC).

Shares Held (Direct Ownership) 869K

4.43% 3M change

129.24% 12M change

Total Value Held $2.1 Million

Esther Rajavelu Transaction History

Date	Transaction	Value	Shares Traded	Shares Held
Nov 07 2025	SELL Open market or private sale	$95,439 $2.37 p/Share	40,270 Reduced 4.43%	869,450 Common Stock
May 02 2025	BUY Grant, award, or other acquisition	-	185,000 Added 16.9%	909,720 Common Stock
Feb 05 2025	SELL Open market or private sale	$16,137 $0.78 p/Share	20,689 Reduced 2.78%	724,720 Common Stock
Feb 03 2025	BUY Grant, award, or other acquisition	-	366,139 Added 32.94%	745,409 Common Stock
Nov 08 2024	SELL Open market or private sale	$22,418 $1.3 p/Share	17,245 Reduced 4.35%	379,270 Common Stock
Nov 07 2024	SELL Open market or private sale	$30,589 $1.31 p/Share	23,351 Reduced 5.56%	396,515 Common Stock
Feb 01 2024	BUY Grant, award, or other acquisition	-	119,866 Added 22.21%	419,866 Common Stock

Nov 13 2023	BUY Grant, award, or other acquisition	-	300,000 Added 50.0%	300,000 Common Stock

Also insider at

FULC

Fulcrum Therapeutics, Inc. Healthcare

Chief Financial Officer

Esther Rajavelu

Cambridge, MA

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